L-Tetrahydropalmatine ( L-THP) is an alkaloid found in several plant species such as Corydalis and Stephania. Corydalis Tuber ( Corydalis yanhusuo) containing L-THP has been used for traditional Chinese pain medicine. Since L-THP antagonizes dopamine D 1 /D 2 receptors and acts on dopamine D 3 receptors, as well as α-adrenergic and serotonin receptors, it may have utility for treating opioid addiction. 1,2)
Furthermore, it has been reported that L-THP shows activity against antineoplastic resistant cancer cells. 3) In antineoplastic resistant cells, p-glycoprotein (P-gp), multidrug resistance-associated protein 1 (MRP1), and breast cancer resistance protein (BCPR), pump some antineoplastic agents out of cells. The P-gp-inhibitory activity of L-THP results in increased doxorubicin cytotoxicity in P-gp-mediated multidrug resistant cancer cells.
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Plant Alkaloid Effective in Multidrug Resistant Cancer Cells
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References
- 1)(−)-Tetrahydropalmatine and its analogues as new dopamine receptor antagonists
- 2) l-tetrahydropalamatine: a potential new medication for the treatment of cocaine addiction
- 3)The two enantiomers of tetrahydropalmatine are inhibitors of P-gp, but not inhibitors of MRP1 or BCRP
