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Novel Aromatic Trifluoromethylating Reagent
Trifluoromethylated aromatic compounds are important intermediates for the synthesis of pharmaceuticals, agrochemicals, and polymer materials, and thus, a number of trifluoromethylating reagents have been developed so far. (Trifluoromethyl)tris(triphenylphosphine)copper(I) (1), reported by Komiya1) and Grushin2) et al., is an air-stable trifluoromethylating reagent with ease of handling, and the reagent has been reported to trifluoromethylate iodoarenes in the presence of tBu-bpy.
References
- 1)C-Si bond cleavage of trihalomethyltrimethylsilane by alkoxo- and aryloxogold or -copper complexes
- 2)Simple, stable, and easily accessible well-defined CuCF3 aromatic trifluoromethylating agents
