Maintenance Notice (10:30 PM June 7 - 2:00 AM June 8, 2025 UTC): This website is scheduled to be unavailable due to maintenance. We appreciate your patience and understanding.
Product Document Searching Made Easy by 2D Code! | TCI Chemistry News June 2025 | [Product Highlights] Benzoquinone Derivative Useful for... | Various analytical charts can be searched on each product detail page and Product Document Search (The kinds of analytical charts differ by product)
Maximum quantity allowed is 999
Please select the quantity
Pd-Catalyzed ortho-Acylation of Acetanilide with Aldehyde through Direct C-H Bond Activation
Wang and Li et al. have reported a Pd catalyzed direct ortho-acylation of acetanilides with aldehydes affording the o-acyl acetanilides. In this study, Pd(OCOCF3)2 gave the best result as a Pd catalyst for the coupling reaction in the presence of tert-butyl hydroperoxide. They have proposed that it is effective to form the palladacycle intermediate when a highly cationic Pd(II) species, Pd(OCOCF3)2 is used;" it easily dissociates into a trifluoroacetate anion and a cationic Pd(II) species compared with that of Pd(OAc)2.
