3',4',5,7-Tetrahydroxyflavone

References

• 1) Luteolin increases susceptibility to macrolides by inhibiting MsrA efflux pump in Trueperella pyogenes
  • Y. Guo, C. Huang, H. Su, Z. Zhang, M. Chen, R. Wang, D. Zhang, L. Zhang, M. Liu, Vet. Res. 2022, 53, 3.
• 2) A Mass Spectrometry-Based Assay for Improved Quantitative Measurements of Efflux Pump Inhibition
  • A.R. Brown et al., PLoS ONE, 2015, 10, e0124814.
• 3) Effects of Luteolin and Quercetin in Combination with Some Conventional Antibiotics against Methicillin-Resistant Staphylococcus aureus
  • M. Usman Amin et al., Int. J. Mol. Sci. 2016, 17, 1947.


Application
Quorum sensing research / Biofilm research

References

• Luteolin Inhibits the Biofilm Formation and Cytotoxicity of Methicillin-Resistant Staphylococcus aureus via Decreasing Bacterial Toxin Synthesis
  • Y. Sun, F. Sun, W. Feng, Q. Wang, F. Liu, P. Xia, X. Qiu, Evid. Based Complement. Alternat. Med. 2022, 2022, 4476339.
• Antibiofilm Efficacy of Luteolin Against Single and Dual Species of Candida albicans and Enterococcus faecalis
  • Y. Fu, W. Wang, Q. Zeng, T. Wang, W. Qian, Front. Microbiol. 2021, 12, 715156.
• The flavanone naringenin reduces the production of quorum sensing-controlled virulence factors in Pseudomonas aeruginosa PAO1
  • O.M. Vandeputte et al., Microbiology 2011, 157, 2120.


Application
Luteolin: A Common Flavonoid with Multiple Biological Effects
Luteolin, 3',4',5,7-tetrahydroxyflavone, is a common flavonoid that exists in many types of plants including dendranthema morifolium and medicinal herbs. It has been reported that luteolin exerts multiple biological effects, such as anti-oxidant, anti-inflammation, anti-allergy, antimicrobial and anticancer activities through pathways. (The product is for research purpose only.)

References

• Isolation of Luteolin and Luteolin-7-O-glucoside from Dendranthema morifolium Ramat Tzvel and Their Pharmacokinetics in Rats
  • L.-C. Lin, Y.-F. Pai, T.-H. Tsai, J. Agric. Food Chem. 2015, 63, 7700.
• Distribution and biological activities of the flavonoid luteolin (a review)
  • M. Lopez-Lazaro, Mini-Rev. Med. Chem. 2009, 9, 31.
• Luteolin, a flavonoid with potential for cancer prevention and therapy (a review)
  • Y. Lin, R. Shi, X. Wang, H.-M. Shen, Curr. Cancer Drug Targets 2008, 8, 634.
• Luteolin, a flavonoid, as an anticancer agent: A review
  • M. Imran, A. Rauf, T. Abu-Izneid, M. Nadeem, M. A. Shariati, I. A. Khan, A. Imran, I. E. Orhan, M. Rizwan, M. Atif, T. A. Gondal, M. S. Mubarak, Biomed. Pharmacother. 2019, 112, 108612.


PubMed Literature