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CAS RN: 54965-24-1 | ์ œํ’ˆ๋ฒˆํ˜ธ: T2510

Tamoxifen Citrate

Thumbnail of Tamoxifen Citrate
  • Chemical Structure of Tamoxifen Citrate
Chemical Structure of Tamoxifen Citrate
× Tamoxifen Citrate

์ˆœ๋„/๋ถ„์„ ๋ฐฉ๋ฒ•: >98.0%(T)(HPLC)
๋™์˜์–ด์˜:
  • (Z)-1-(4-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene Citrate
์ œํ’ˆ๋ฌธ์„œ:
SDS | ๊ทœ๊ฒฉํ‘œ | ์‹œํ—˜์„ฑ์ ์„œ๏ผŒ ๊ฐ์ข… ์ฆ๋ช…์„œ | ๋ถ„์„ ์ฐจํŠธ

์ผ๋ฐ˜ ์ •๋ณด | ๊ทœ๊ฒฉ์น˜/๋ฌผ์„ฑ์น˜ | ์•ˆ์ „ ๋ฐ ๊ทœ์ • | ์ด์šฉ ์˜ˆใƒป๋ฌธํ—Œ

์ด ํŽ˜์ด์ง€์— ๋Œ€ํ•œ ์„ค๋ช…

1G
โ‚ฉ200,900
 13   14   ์ฃผ๋ฌธ ํ›„ 2์ฃผ ์ •๋„ ์†Œ์š”๋ฉ๋‹ˆ๋‹ค
์ถœํ•˜ ์‹œ๋ฎฌ๋ ˆ์ด์…˜
5G
โ‚ฉ700,100
 10   38   ์ฃผ๋ฌธ ํ›„ 2์ฃผ ์ •๋„ ์†Œ์š”๋ฉ๋‹ˆ๋‹ค
์ถœํ•˜ ์‹œ๋ฎฌ๋ ˆ์ด์…˜
โ€ข๋ณธ ์ œํ’ˆ์˜ ์žฌ๊ณ ๋Š” ์ผ๋ณธ ๋ณธ์‚ฌ์˜ ์žฌ๊ณ ์ž…๋‹ˆ๋‹ค. ์ฃผ๋ฌธ์‹œ, 5์ผ์•ˆ์— ์‹คํ—˜์‹ค๊นŒ์ง€ ๋„์ฐฉ๋ฉ๋‹ˆ๋‹ค.
โ€ข๋ณธ๊ฑด์˜ ์›๊ฐ€๊ฒฉ์€ ํ•œ๊ตญ ๋Œ€๋ฆฌ์ ์˜ ์˜ˆ์ƒ ํŒ๋งค๊ฐ€๊ฒฉ์ž…๋‹ˆ๋‹ค.์ž์„ธํ•œ ์ •๋ณด๊ฐ€ ํ•„์š”ํ•˜์‹œ๋ฉด ์—ฐ๋ฝํ•ด ์ฃผ์‹ญ์‹œ์˜ค.( SEJIN CI Co., Ltd. (ํ•œ๊ตญ์ด๋Œ€๋ฆฌ์ ) ์ „ํ™” : 02-2655-2480 ์ด๋ฉ”์ผ :  sales@sejinci.co.kr)
โ€ข๋ณด๊ด€ ์กฐ๊ฑด์€ ์˜ˆ๊ณ ์—†์ด ๋ณ€๊ฒฝ ๋  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ์ œํ’ˆ ๋ณด๊ด€ ์กฐ๊ฑด์˜ ์ตœ์‹  ์ž๋ฃŒ๋Š” ํ™ˆํŽ˜์ด์ง€์— ๊ธฐ์žฌ๋˜์–ด ์žˆ์œผ๋‹ˆ ์–‘ํ•ด ๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค.
์ œํ’ˆ๋ฒˆํ˜ธ T2510
Purity/Analysis Method >98.0%(T)(HPLC)
M.F. / M.W. C__2__6H__2__9NOยทC__6H__8O__7 = 563.65 
๋ฌผ๋ฆฌ์  ์ƒํƒœ (20 โ„ƒ) Solid
๋ณด๊ด€ ์กฐ๊ฑด Refrigerated (0-10ยฐC)
๋ถˆํ™œ์„ฑ ๊ฐ€์Šค ํ•˜์—์„œ ๋ณด๊ด€ Store under inert gas
ํ”ผํ•ด์•ผ ํ•  ์กฐ๊ฑด Light Sensitive,Hygroscopic,Heat Sensitive
์šฉ๊ธฐ 1G-Glass Bottle with Plastic Insert (์ด๋ฏธ์ง€ ๋ณด๊ธฐ)
CAS RN 54965-24-1
๊ด€๋ จ CAS RN 10540-29-1
Reaxys-RN 8888650
PubChem Substance ID 87560062
Merck Index (14) 9048
MDL ๋ฒˆํ˜ธ

MFCD00058321
๊ทœ๊ฒฉํ‘œ
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
๋ฌผ์„ฑ์น˜(์ฐธ๊ณ ์น˜)
mp 142 ยฐC(dec.)
Solubility in water Slightly soluble
์šฉํ•ด์„ฑ (์šฉํ•ด) Methanol, Acetone, Ethanol
GHS
ํ”ฝํ† ๊ทธ๋žจ Pictogram Pictogram
์‹ ํ˜ธ ์›Œ๋“œ Danger
์œ„ํ—˜๋ฌผ ๋ฐ ์œ ํ•ด ๋“ฑ๋ก H302 : Harmful if swallowed.
H360 : May damage fertility or the unborn child.
H362 : May cause harm to breast-fed children.
H350 : May cause cancer.
์ฃผ์˜ ์‚ฌํ•ญ P501 : Dispose of contents/ container to an approved waste disposal plant.
P263 : Avoid contact during pregnancy/ while nursing.
P260 : Do not breathe dusts or mists.
P270 : Do not eat, drink or smoke when using this product.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
P405 : Store locked up.
๋ฒ•๊ทœ ์ •๋ณด
RTECS # KH2387000
์šด์†ก ์ •๋ณด
HS ๋ฒˆํ˜ธ* 2921.49-000
*์ด HS ๋ฒˆํ˜ธ ๋Š” TCI(์ผ๋ณธ)์—์„œ ์ œํ’ˆ์„ ์ˆ˜์ถœํ•  ๋•Œ๋งŒ ์‚ฌ์šฉ๋ฉ๋‹ˆ๋‹ค
Application
Tamoxifen Citrate: Selective Estrogen Receptor Modulator (SERM)

Tamoxifen citrate is a widely used nonsteroidal anti-estrogen agent for the treatment of hormone-dependent breast cancer. Tamoxifen is a prodrug and extensively metabolized by cytochrome P450 (CYP450) enzymes into active metabolites including 4-hydroxytamoxifen [H1693] and endoxifen (4-hydroxy-N-desmethyltamoxifen). Each acts as an estrogen receptor antagonist in breast tissue. Tamoxifen is commonly referred to as a selective estrogen receptor modulator (SERM), since it behaves as an estrogen receptor agonist in other tissues. (The product is for research purpose only.)

References


Application
Tamoxifen Citrate: Selective Estrogen Receptor Modulator (SERM)

Tamoxifen citrate is a widely used nonsteroidal anti-estrogen agent for the treatment of hormone-dependent breast cancer. Tamoxifen is a prodrug and extensively metabolized by cytochrome P450 (CYP450) enzymes into active metabolites including 4-hydroxytamoxifen and endoxifen (4-hydroxy-N-desmethyltamoxifen). They act as an estrogen receptor antagonist in breast tissue. Tamoxifen is commonly referred to as a selective estrogen receptor modulator (SERM), since it behaves as an estrogen receptor agonist in other tissues. (The product is for research purpose only.)

References


PubMed Literature


๋ฌธ์„œ

์ œํ’ˆ๊ธฐ์‚ฌ
์ œํ’ˆ๋ฌธ์„œ (๋ถ„์„ ์ฐจํŠธ๋ฅผ ์ œ๊ณตํ•˜์ง€ ๋ชปํ•  ์ˆ˜๋„ ์žˆ์œผ๋‹ˆ ์–‘ํ•ด ๋ฐ”๋ž๋‹ˆ๋‹ค.)
SDS
์–ธ์–ด๋ฅผ ์„ ํƒํ•˜์‹ญ์‹œ์˜ค.

์š”์ฒญํ•œ SDS๋ฅผ ์‚ฌ์šฉํ•  ์ˆ˜ ์—†์Šต๋‹ˆ๋‹ค.

๋ฒˆ๊ฑฐ๋กญ๊ฒŒ ํ•ด๋“œ๋ ค ์ฃ„์†กํ•˜์ง€๋งŒ ์ด ์–‘์‹ ๋ณด๋‹ค ๋ฌธ์˜ ํ•ด์ฃผ์‹ญ์‹œ์˜ค.
๊ทœ๊ฒฉํ‘œ
์‹œํ—˜์„ฑ์ ์„œ๏ผŒ ๊ฐ์ข… ์ฆ๋ช…์„œ
๋กฏํŠธ ๋ฒˆํ˜ธ๋ฅผ ์ž…๋ ฅํ•˜์‹ญ์‹œ์˜ค. ์ž˜๋ชป๋œ ๋กœํŠธ ๋ฒˆํ˜ธ๊ฐ€ ์ž…๋ ฅ๋˜์—ˆ์Šต๋‹ˆ๋‹ค.

๊ฒ€์ƒ‰ํ•˜์‹  ๋กœํŠธ ๋ฒˆํ˜ธ๋Š” ํ˜„์žฌ ์‚ฌ์šฉ์ด ๋ถˆ๊ฐ€๋Šฅํ•˜๋ฉฐ, ๊ด€๋ จ ๋ฌธ์„œ๋„ ์ œ๊ณต๋˜์ง€ ์•Š์Šต๋‹ˆ๋‹ค. ์ด ์ œํ’ˆ์— ๋Œ€ํ•ด์„œ๋Š” ๋‹ค๋ฅธ ๋กœํŠธ ๋ฒˆํ˜ธ๋ฅผ ์ž…๋ ฅํ•ด ์ฃผ์‹œ๊ธฐ ๋ฐ”๋ž๋‹ˆ๋‹ค.
์ƒ˜ํ”Œ ์‹œํ—˜์„ฑ์ ์„œ
์‹œํ—˜์„ฑ์ ์„œ ์ƒ˜ํ”Œ์„ ๋‹ค์šด๋กœ๋“œํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ์ƒ˜ํ”Œ์€ ๋ฐ˜๋“œ์‹œ ์ตœ์‹  ๋กœํŠธ์˜ ๊ฒฐ๊ณผ๋ฅผ ๋‚˜ํƒ€๋‚ด๋Š” ๊ฒƒ์€ ์•„๋‹™๋‹ˆ๋‹ค.

๋ณธ ์ œํ’ˆ์˜ ์ƒ˜ํ”Œ์‹œํ—˜์„ฑ์ ์„œ๋Š” ํ˜„์žฌ ์ค€๋น„๋˜์–ด ์žˆ์ง€ ์•Š์Šต๋‹ˆ๋‹ค.

๋ถ„์„ ์ฐจํŠธ
๋กฏํŠธ ๋ฒˆํ˜ธ๋ฅผ ์ž…๋ ฅํ•˜์‹ญ์‹œ์˜ค. ์ž˜๋ชป๋œ ๋กœํŠธ ๋ฒˆํ˜ธ๊ฐ€ ์ž…๋ ฅ๋˜์—ˆ์Šต๋‹ˆ๋‹ค.

์ฃ„์†กํ•ฉ๋‹ˆ๋‹ค๋งŒ ์ฐพ์œผ์‹œ๋Š” ๋ถ„์„์ฐจํŠธ๋Š” ์—†์Šต๋‹ˆ๋‹ค.

๊ฒ€์ƒ‰ํ•˜์‹  ๋กœํŠธ ๋ฒˆํ˜ธ๋Š” ํ˜„์žฌ ์‚ฌ์šฉ์ด ๋ถˆ๊ฐ€๋Šฅํ•˜๋ฉฐ, ๊ด€๋ จ ๋ฌธ์„œ๋„ ์ œ๊ณต๋˜์ง€ ์•Š์Šต๋‹ˆ๋‹ค. ์ด ์ œํ’ˆ์— ๋Œ€ํ•ด์„œ๋Š” ๋‹ค๋ฅธ ๋กœํŠธ ๋ฒˆํ˜ธ๋ฅผ ์ž…๋ ฅํ•ด ์ฃผ์‹œ๊ธฐ ๋ฐ”๋ž๋‹ˆ๋‹ค.
๊ธฐํƒ€ ์„œ๋ฅ˜

์„ธ์…˜ ์ƒํƒœ
์„ธ์…˜์˜ ๋‚จ์€ ์‹œ๊ฐ„์€ 10๋ถ„์ž…๋‹ˆ๋‹ค. ์ด๋Œ€๋กœ ๋ฐฉ์น˜ํ•˜๋ฉด ์„ธ์…˜์ด ๋Š์–ด์ง€๊ณ  ํƒ‘ํŽ˜์ด์ง€๋กœ ๋Œ์•„๊ฐ‘๋‹ˆ๋‹ค. ๊ฐ™์€ ํŽ˜์ด์ง€์—์„œ ์„ธ์…˜์„ ๊ณ„์†ํ•˜๋ ค๋ฉด ๋ฒ„ํŠผ์„ ํด๋ฆญํ•˜์‹ญ์‹œ์˜ค.๋ถ„์ž…๋‹ˆ๋‹ค. ์ด๋Œ€๋กœ ๋ฐฉ์น˜ํ•˜๋ฉด ์„ธ์…˜์ด ๋Š์–ด์ง€๊ณ  ํƒ‘ํŽ˜์ด์ง€๋กœ ๋Œ์•„๊ฐ‘๋‹ˆ๋‹ค. ๊ฐ™์€ ํŽ˜์ด์ง€์—์„œ ์„ธ์…˜์„ ๊ณ„์†ํ•˜๋ ค๋ฉด ๋ฒ„ํŠผ์„ ํด๋ฆญํ•˜์‹ญ์‹œ์˜ค.
๊ณ„์†
์„ธ์…˜์ด ์‹œ๊ฐ„ ์ดˆ๊ณผ๋˜์—ˆ์Šต๋‹ˆ๋‹ค. ํƒ‘ํŽ˜์ด์ง€๋กœ ๋Œ์•„๊ฐ‘๋‹ˆ๋‹ค.
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