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CAS RN: 50-07-7 | ์ ํ๋ฒํธ: M2320
Ametycin
×
์๋/๋ถ์ ๋ฐฉ๋ฒ: >98.0%(HPLC)
๋์์ด์:
- Mitomycin C
์ ํ๋ฌธ์:
| ํฌ์ฅ๋จ์ | ๊ฐ๊ฒฉ | ๋น์ผ์ถ๊ณ | 2-3์ผ ์ด๋ด ์ถ๊ณ | ์ถ๊ฐ๋ก ํ์ํ ๊ฒฝ์ฐ |
์ถํ ์ ๋ณด
|
|---|---|---|---|---|---|
| 10MG |
โฉ210,600
|
34 | ≥60 | ์ฃผ๋ฌธ ํ 2์ฃผ ์ ๋ ์์๋ฉ๋๋ค | |
| 50MG |
โฉ717,600
|
3 | ≥80 | ์ฃผ๋ฌธ ํ 2์ฃผ ์ ๋ ์์๋ฉ๋๋ค |
โข๋ณธ ์ ํ์ ์ฌ๊ณ ๋ ์ผ๋ณธ ๋ณธ์ฌ์ ์ฌ๊ณ ์
๋๋ค. ์ฃผ๋ฌธ์, 5์ผ์์ ์คํ์ค๊น์ง ๋์ฐฉ๋ฉ๋๋ค.
โข๋ณธ๊ฑด์ ์๊ฐ๊ฒฉ์ ํ๊ตญ ๋๋ฆฌ์ ์ ์์ ํ๋งค๊ฐ๊ฒฉ์ ๋๋ค.์์ธํ ์ ๋ณด๊ฐ ํ์ํ์๋ฉด ์ฐ๋ฝํด ์ฃผ์ญ์์ค.( SEJIN CI Co., Ltd. (ํ๊ตญ์ด๋๋ฆฌ์ ) ์ ํ : 02-2655-2480 ์ด๋ฉ์ผ : sales@sejinci.co.kr)
โข๋ณด๊ด ์กฐ๊ฑด์ ์๊ณ ์์ด ๋ณ๊ฒฝ ๋ ์ ์์ต๋๋ค. ์ ํ ๋ณด๊ด ์กฐ๊ฑด์ ์ต์ ์๋ฃ๋ ํํ์ด์ง์ ๊ธฐ์ฌ๋์ด ์์ผ๋ ์ํด ๋ถํ๋๋ฆฝ๋๋ค.
โข๋ณธ๊ฑด์ ์๊ฐ๊ฒฉ์ ํ๊ตญ ๋๋ฆฌ์ ์ ์์ ํ๋งค๊ฐ๊ฒฉ์ ๋๋ค.์์ธํ ์ ๋ณด๊ฐ ํ์ํ์๋ฉด ์ฐ๋ฝํด ์ฃผ์ญ์์ค.( SEJIN CI Co., Ltd. (ํ๊ตญ์ด๋๋ฆฌ์ ) ์ ํ : 02-2655-2480 ์ด๋ฉ์ผ : sales@sejinci.co.kr)
โข๋ณด๊ด ์กฐ๊ฑด์ ์๊ณ ์์ด ๋ณ๊ฒฝ ๋ ์ ์์ต๋๋ค. ์ ํ ๋ณด๊ด ์กฐ๊ฑด์ ์ต์ ์๋ฃ๋ ํํ์ด์ง์ ๊ธฐ์ฌ๋์ด ์์ผ๋ ์ํด ๋ถํ๋๋ฆฝ๋๋ค.
| ์ ํ๋ฒํธ | M2320 |
Purity/Analysis Method 
|
>98.0%(HPLC) |
| M.F. / M.W. | C__1__5H__1__8N__4O__5 = 334.33 |
| ๋ฌผ๋ฆฌ์ ์ํ (20 โ) | Solid |
| ๋ณด๊ด ์กฐ๊ฑด
|
Refrigerated (0-10ยฐC) |
| ํผํด์ผ ํ ์กฐ๊ฑด | Heat Sensitive |
| ์ฉ๊ธฐ
|
10MG-Glass Bottle with Plastic Insert (์ด๋ฏธ์ง ๋ณด๊ธฐ), 50MG-Glass Bottle with Plastic Insert (์ด๋ฏธ์ง ๋ณด๊ธฐ) |
| CAS RN | 50-07-7 |
| Reaxys-RN | 3570056 |
| PubChem Substance ID | 172088986 |
| Merck Index (14) | 6215 |
| MDL ๋ฒํธ | MFCD00078109 |
๊ท๊ฒฉํ
| Appearance | Dark red to Dark purple to Dark blue powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 16.4 to 17.0 % |
| NMR | confirm to structure |
๋ฌผ์ฑ์น(์ฐธ๊ณ ์น)
| mp | 360 ยฐC |
GHS
| ํฝํ ๊ทธ๋จ |
|
| ์ ํธ ์๋ | Danger |
| ์ํ๋ฌผ ๋ฐ ์ ํด ๋ฑ๋ก | H300 : Fatal if swallowed. H361 : Suspected of damaging fertility or the unborn child. H351 : Suspected of causing cancer. |
| ์ฃผ์ ์ฌํญ | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
๋ฒ๊ท ์ ๋ณด
| RTECS # | CN0700000 |
์ด์ก ์ ๋ณด
| UN ๋ฒํธ | UN2811 |
| ๋ฑ๊ธ | 6.1 |
| ํฌ์ฅ ๊ทธ๋ฃน | II |
| HS ๋ฒํธ* | 2941.90-000 |
Application
Ametycin: A DNA Interstrand Cross-Linking Agent
Ametycin (also known as Mitomycin C) is an antitumor antibiotic and a bifunctional alkylating agent, first isolated from the broth filtrate of Streptomyces caespitosus by Hata et al. (Kitasato Institute) in 1955. Some metabolic activation forms of ametycin inhibit DNA synthesis by causing cross-linking specificity for the sequence CpG. Ametycin causes cell cycle arrest in phase-nonspecific but is most active in S and G phases, and induces apoptosis in cancer cells.
References
- Isolation and structure of a covalent cross-link adduct between mitomycin C and DNA
- DT-diaphorase in activation and detoxification of quinones: bioreductive activation of mitomycin C (a review)
- Mitomycin C: small, fast and deadly (but very selective) (a review)
- The mitomycin bioreductive antitumor agents: crosslinking and alkylation of DNA as the molecular basis of their activity (a review)
- Formation and Repair of Interstrand Cross-Links in DNA (a review)
PubMed Literature
๋ฌธ์
์ ํ๊ธฐ์ฌ
์ ํ๋ฌธ์ (๋ถ์ ์ฐจํธ๋ฅผ ์ ๊ณตํ์ง ๋ชปํ ์๋ ์์ผ๋ ์ํด ๋ฐ๋๋๋ค.)
SDS
์ธ์ด๋ฅผ ์ ํํ์ญ์์ค.
์์ฒญํ SDS๋ฅผ ์ฌ์ฉํ ์ ์์ต๋๋ค.
๋ฒ๊ฑฐ๋กญ๊ฒ ํด๋๋ ค ์ฃ์กํ์ง๋ง ์ด ์์ ๋ณด๋ค ๋ฌธ์ ํด์ฃผ์ญ์์ค.
๊ท๊ฒฉํ
์ํ์ฑ์ ์๏ผ ๊ฐ์ข ์ฆ๋ช ์
๋กฏํธ ๋ฒํธ๋ฅผ ์
๋ ฅํ์ญ์์ค.
์๋ชป๋ ๋กํธ ๋ฒํธ๊ฐ ์
๋ ฅ๋์์ต๋๋ค.
์ํ ์ํ์ฑ์ ์
์ํ์ฑ์ ์ ์ํ์ ๋ค์ด๋ก๋ํ ์ ์์ต๋๋ค. ์ํ์ ๋ฐ๋์ ์ต์ ๋กํธ์ ๊ฒฐ๊ณผ๋ฅผ ๋ํ๋ด๋ ๊ฒ์ ์๋๋๋ค.
๋ณธ ์ ํ์ ์ํ์ํ์ฑ์ ์๋ ํ์ฌ ์ค๋น๋์ด ์์ง ์์ต๋๋ค.
๋ถ์ ์ฐจํธ
๋กฏํธ ๋ฒํธ๋ฅผ ์
๋ ฅํ์ญ์์ค.
์๋ชป๋ ๋กํธ ๋ฒํธ๊ฐ ์
๋ ฅ๋์์ต๋๋ค.
์ฃ์กํฉ๋๋ค๋ง ์ฐพ์ผ์๋ ๋ถ์์ฐจํธ๋ ์์ต๋๋ค.