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CAS RN: 99011-02-6 | ์ ํ๋ฒํธ: I0747
Imiquimod
์๋/๋ถ์ ๋ฐฉ๋ฒ: >98.0%(T)(HPLC)
๋์์ด์:
- 1-Isobutyl-1H-imidazo[4,5-c]quinolin-4-amine
- 4-Amino-1-isobutyl-1H-imidazo[4,5-c]quinoline
์ ํ๋ฌธ์:
โข๋ณธ ์ ํ์ ์ฌ๊ณ ๋ ์ผ๋ณธ ๋ณธ์ฌ์ ์ฌ๊ณ ์
๋๋ค. ์ฃผ๋ฌธ์, 5์ผ์์ ์คํ์ค๊น์ง ๋์ฐฉ๋ฉ๋๋ค.
โข๋ณธ๊ฑด์ ์๊ฐ๊ฒฉ์ ํ๊ตญ ๋๋ฆฌ์ ์ ์์ ํ๋งค๊ฐ๊ฒฉ์ ๋๋ค.์์ธํ ์ ๋ณด๊ฐ ํ์ํ์๋ฉด ์ฐ๋ฝํด ์ฃผ์ญ์์ค.( SEJIN CI Co., Ltd. (ํ๊ตญ์ด๋๋ฆฌ์ ) ์ ํ : 02-2655-2480 ์ด๋ฉ์ผ : sales@sejinci.co.kr)
โข๋ณด๊ด ์กฐ๊ฑด์ ์๊ณ ์์ด ๋ณ๊ฒฝ ๋ ์ ์์ต๋๋ค. ์ ํ ๋ณด๊ด ์กฐ๊ฑด์ ์ต์ ์๋ฃ๋ ํํ์ด์ง์ ๊ธฐ์ฌ๋์ด ์์ผ๋ ์ํด ๋ถํ๋๋ฆฝ๋๋ค.
โข๋ณธ๊ฑด์ ์๊ฐ๊ฒฉ์ ํ๊ตญ ๋๋ฆฌ์ ์ ์์ ํ๋งค๊ฐ๊ฒฉ์ ๋๋ค.์์ธํ ์ ๋ณด๊ฐ ํ์ํ์๋ฉด ์ฐ๋ฝํด ์ฃผ์ญ์์ค.( SEJIN CI Co., Ltd. (ํ๊ตญ์ด๋๋ฆฌ์ ) ์ ํ : 02-2655-2480 ์ด๋ฉ์ผ : sales@sejinci.co.kr)
โข๋ณด๊ด ์กฐ๊ฑด์ ์๊ณ ์์ด ๋ณ๊ฒฝ ๋ ์ ์์ต๋๋ค. ์ ํ ๋ณด๊ด ์กฐ๊ฑด์ ์ต์ ์๋ฃ๋ ํํ์ด์ง์ ๊ธฐ์ฌ๋์ด ์์ผ๋ ์ํด ๋ถํ๋๋ฆฝ๋๋ค.
์ ํ๋ณด์ถฉ์ ๋ณด:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| ์ ํ๋ฒํธ | I0747 |
Purity/Analysis Method
|
>98.0%(T)(HPLC) |
| M.F. / M.W. | C__1__4H__1__6N__4 = 240.31 |
| ๋ฌผ๋ฆฌ์ ์ํ (20 โ) | Solid |
๋ณด๊ด ์กฐ๊ฑด
|
Room Temperature (Recommended in a cool and dark place, <15ยฐC) |
์ฉ๊ธฐ
|
100MG-Glass Bottle with Plastic Insert (์ด๋ฏธ์ง ๋ณด๊ธฐ), 1G-Glass Bottle with Plastic Insert (์ด๋ฏธ์ง ๋ณด๊ธฐ) |
| CAS RN | 99011-02-6 |
| Reaxys-RN | 7710060 |
| PubChem Substance ID | 87561300 |
| Merck Index (14) | 4922 |
| MDL ๋ฒํธ | MFCD00866946 |
๊ท๊ฒฉํ
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
๋ฌผ์ฑ์น(์ฐธ๊ณ ์น)
| mp | 294 ยฐC |
| Maximum Wavelength | 245 nm (H__2O/MeOH) |
GHS
| ํฝํ ๊ทธ๋จ |
|
| ์ ํธ ์๋ | Danger |
| ์ํ๋ฌผ ๋ฐ ์ ํด ๋ฑ๋ก | H301 : Toxic if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| ์ฃผ์ ์ฌํญ | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
๋ฒ๊ท ์ ๋ณด
| RTECS # | NJ5903450 |
์ด์ก ์ ๋ณด
| UN ๋ฒํธ | UN2811 |
| ๋ฑ๊ธ | 6.1 |
| ํฌ์ฅ ๊ทธ๋ฃน | III |
| HS ๋ฒํธ* | 2933.99-000 |
Application
Imiquimod: A Toll-Like Receptor (TLR) 7 Agonist and a Potent Immune Activator
Imiquimod is reported as a Toll-like receptor (TLR) 7 agonist and a potent immune activator. Imiquimod activates innate immune cells to produce interferon-α (IFN-α) and other cytokines both in vitro and in vivo. This immune-based mechanism provides activity against a number of viruses. In addition, it is also used for a reagent for inflammation and immunity disorder models. (The product is for research purpose only.)
References
- Imiquimod applied topically: a novel immune response modifier and new class of drug
- Imiquimod and resiquimod as novel immunomodulators
- Imiquimod and the imidazoquinolones: mechanism of action and therapeutic potential
- Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway
- The antiviral activity of toll-like receptor 7 and 7/8 agonists
- Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice Is Mediated via the IL-23/IL-17 Axis
PubMed Literature
๋ฌธ์
์ ํ๊ธฐ์ฌ
์ ํ๋ฌธ์ (๋ถ์ ์ฐจํธ๋ฅผ ์ ๊ณตํ์ง ๋ชปํ ์๋ ์์ผ๋ ์ํด ๋ฐ๋๋๋ค.)
SDS
์ธ์ด๋ฅผ ์ ํํ์ญ์์ค.
์์ฒญํ SDS๋ฅผ ์ฌ์ฉํ ์ ์์ต๋๋ค.
๋ฒ๊ฑฐ๋กญ๊ฒ ํด๋๋ ค ์ฃ์กํ์ง๋ง ์ด ์์ ๋ณด๋ค ๋ฌธ์ ํด์ฃผ์ญ์์ค.
๊ท๊ฒฉํ
์ํ์ฑ์ ์๏ผ ๊ฐ์ข ์ฆ๋ช ์
๋กฏํธ ๋ฒํธ๋ฅผ ์
๋ ฅํ์ญ์์ค.
์๋ชป๋ ๋กํธ ๋ฒํธ๊ฐ ์
๋ ฅ๋์์ต๋๋ค.
์ํ ์ํ์ฑ์ ์
์ํ์ฑ์ ์ ์ํ์ ๋ค์ด๋ก๋ํ ์ ์์ต๋๋ค. ์ํ์ ๋ฐ๋์ ์ต์ ๋กํธ์ ๊ฒฐ๊ณผ๋ฅผ ๋ํ๋ด๋ ๊ฒ์ ์๋๋๋ค.
๋ณธ ์ ํ์ ์ํ์ํ์ฑ์ ์๋ ํ์ฌ ์ค๋น๋์ด ์์ง ์์ต๋๋ค.
๋ถ์ ์ฐจํธ
๋กฏํธ ๋ฒํธ๋ฅผ ์
๋ ฅํ์ญ์์ค.
์๋ชป๋ ๋กํธ ๋ฒํธ๊ฐ ์
๋ ฅ๋์์ต๋๋ค.
์ฃ์กํฉ๋๋ค๋ง ์ฐพ์ผ์๋ ๋ถ์์ฐจํธ๋ ์์ต๋๋ค.