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CAS RN: 383418-30-2 | 제품번호: H1553
HPA-12
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| 포장단위 | 가격 | 당일출고 | 2-3일 이내 출고 | 추가로 필요한 경우 |
출하 정보
|
|---|---|---|---|---|---|
| 5MG |
₩595,700
|
1 | 0 | 주문 후 2주 정도 소요됩니다 |
•본 제품의 재고는 일본 본사의 재고입니다. 주문시, 5일안에 실험실까지 도착됩니다.
•본건의 원가격은 한국 대리점의 예상 판매가격입니다.자세한 정보가 필요하시면 연락해 주십시오.( SEJIN CI Co., Ltd. (한국총대리점) 전화 : 02-2655-2480 이메일 : sales@sejinci.co.kr)
•보관 조건은 예고없이 변경 될 수 있습니다. 제품 보관 조건의 최신 자료는 홈페이지에 기재되어 있으니 양해 부탁드립니다.
•본건의 원가격은 한국 대리점의 예상 판매가격입니다.자세한 정보가 필요하시면 연락해 주십시오.( SEJIN CI Co., Ltd. (한국총대리점) 전화 : 02-2655-2480 이메일 : sales@sejinci.co.kr)
•보관 조건은 예고없이 변경 될 수 있습니다. 제품 보관 조건의 최신 자료는 홈페이지에 기재되어 있으니 양해 부탁드립니다.
규격표
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 3.60 to 4.10 % |
| NMR | confirm to structure |
물성치(참고치)
| 비율 광학 회전 [α]D | -38.9° (C=0.36,CHCl3) |
GHS
법규 정보
운송 정보
| HS 번호* | 2924.29-000 |
Application
HPA-12: An Important Ceramide-Trafficking Inhibitor
HPA-12 is a ceramide (Cer) -trafficking inhibitor that was first discovered and synthesized by Hanada and Kobayashi et al.1-3) Ceramide is synthesized in the endoplasmic reticulum (ER) and is transported to the Golgi apparatus, where it is converted to sphingomyelin, by means of the ceramide transport protein (CERT). HPA-12 inhibits the CERT,6) and has been used as a CERT inhibitor in various biological science studies.7-12) For example, HPA-12 possesses antiviral and antibacterial properties against the growth of hepatitis C virus (HCV) and the obligate intracellular bacteria Chlamydiae in cultured human cells.7,10,11) In addition, the CERT inhibition results in resensitization of cancer cells to chemotherapeutic agents such as paclitaxel [ P1632].8) Meanwhile, a point mutation of CERT gene, which dysregulates the function of CERT,14) causes a mental retardation disorder with autosomal dominant inheritance.13) Therefore, inhibition of CERT may represent medical strategies, such as anti-infective and anticancer chemotherapy. (The product is for research purpose only.)
References
- 1)A novel inhibitor of ceramide trafficking from the endoplasmic reticulum to the site of sphingomyelin synthesis
- 2)Revised Stereochemistry of Ceramide-Trafficking Inhibitor HPA-12 by X-ray Crystallography Analysis
- 3)Identification of Novel CERT Ligands as Potential Ceramide Trafficking Inhibitors
- 4)Molecular machinery for non-vesicular trafficking of ceramide
- 5)Co-evolution of sphingomyelin and the ceramide transport protein CERT (a review)
- 6)CERT mediates intermembrane transfer of various molecular species of ceramides
- 7)Host sphingolipid biosynthesis as a target for hepatitis C virus therapy
- 8)Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs
- 9)Decreased ceramide transport protein (CERT) function alters sphingomyelin production following UVB irradiation
- 10)Critical role of virion-associated cholesterol and sphingolipid in hepatitis C virus infection
- 11)Chlamydia trachomatis co-opts GBF1 and CERT to acquire host sphingomyelin for distinct roles during intracellular development
- 12)Trafficking of Acetyl-C16-Ceramide-NBD with Long-Term Stability and No Cytotoxicity into the Golgi Complex
- 13)Large-scale discovery of novel genetic causes of developmental disorders
- 14)Interorganelle trafficking of ceramide is regulated by phosphorylation-dependent cooperativity between the PH and START domains of CERT
PubMed Literature
기사 / 브로셔
제품문서 (분석 차트를 제공하지 못할 수도 있으니 양해 바랍니다.)
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규격표
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