Hesperidin

Reference

• Hesperidin Induces Paraptosis Like Cell Death in Hepatoblastoma, HepG2 Cells: Involvement of ERK1/2 MAPK
  • S. Yumnam et al., PLoS ONE 2014, 9, e101321.


Application
Quorum sensing research / Biofilm research

References

• Inhibition of Quorum Sensing (QS) in Yersinia enterocolitica by an Orange Extract Rich in Glycosylated Flavanones
• P. Truchado, J.-A. Giménez-Bastida, M. Larrosa, I. Castro-Ibáñez, J.C. Espín, F.A. Tomás-Barberán, M.T. García-Conesa, A. Allende, J. Agric. Food Chem. 2012, 60, 8885.
• Suppression of bacterial cell–cell signalling, biofilm formation and type III secretion system by citrus flavonoids
• A. Vikram, G.K. Jayaprakasha, P.R. Jesudhasan, S.D. Pillai, B.S. Patil, J. Appl. Microbiol. 2010, 109, 515.


Application
Hesperidin: A Flavonoid Compound with Various Physiological Activities
Hesperidin is a flavonoid compound abundantly occulting in citrus fruit peel, and is known as an effective ingredient crud drug (Citrus Unshiu Peel) due to its various physiological functions since long time, such as antioxidant and anti-inflammatory properties.^1,2) The citrus flavanones hesperidin, neohesperidin [N1121], hesperetin [H0721] and naringin [N0073] are known to exhibit antioxidant activities and could cross the blood-brain barrier, and they reportedly have neuroprotective effects against reactive oxygen species (ROS).³⁾ Furthermore, hesperidin is one of the substances like vitamin P and well known to decrease capillary fragility and permeability.¹⁾ In addition, it has been reported that hesperidin reduces the proliferation of many cancer cells.^4,5) (The product is for research purpose only.)

References

• 1) Chemistry and pharmacology of the Citrus bioflavonoid hesperidin (a review)
  • A. Garg, S. Garg, L. J. D. Zaneveld, A. K. Singla, Phytother. Res. 2001, 15, 655.
• 2) Antioxidant and anti-inflammatory properties of the citrus flavonoids hesperidin and hesperetin: an updated review of their molecular mechanisms and experimental models (a review)
  • H. Parhiz, A. Roohbakhsh, F. Soltani, R. Rezaee, M. Iranshahi, Phytother. Res. 2015, 29, 323.
• 3) Neuroprotective effects of citrus flavonoids (a review)
  • S.-L. Hwang, P.-H. Shih, G.-C. Yen, J. Agric. Food Chem. 2012, 60, 877.
• 4) Molecular mechanisms behind the biological effects of hesperidin and hesperetin for the prevention of cancer and cardiovascular diseases (a review)
  • A. Roohbakhsh, H. Parhiz, F. Soltani, R. Rezaee, M. Iranshah, Life Sci. 2015, 124, 64.
• 5) Hesperidin: A promising anticancer agent from nature
  • K. Pandima Devi, T. Rajavel, S. F. Nabavi, W. N. Setzer, A. Ahmadi, K. Mansour, S. M. Nabavi, Ind. Crops Prod. 2015, 76, 582.


PubMed Literature