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CAS RN: 25316-40-9 | 제품번호: D4193
Doxorubicin Hydrochloride
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•본 제품의 재고는 일본 본사의 재고입니다. 주문시, 5일안에 실험실까지 도착됩니다.
•본건의 원가격은 한국 대리점의 예상 판매가격입니다.자세한 정보가 필요하시면 연락해 주십시오.( SEJIN CI Co., Ltd. (한국총대리점) 전화 : 02-2655-2480 이메일 : sales@sejinci.co.kr)
•보관 조건은 예고없이 변경 될 수 있습니다. 제품 보관 조건의 최신 자료는 홈페이지에 기재되어 있으니 양해 부탁드립니다.
•본건의 원가격은 한국 대리점의 예상 판매가격입니다.자세한 정보가 필요하시면 연락해 주십시오.( SEJIN CI Co., Ltd. (한국총대리점) 전화 : 02-2655-2480 이메일 : sales@sejinci.co.kr)
•보관 조건은 예고없이 변경 될 수 있습니다. 제품 보관 조건의 최신 자료는 홈페이지에 기재되어 있으니 양해 부탁드립니다.
| 제품번호 | D4193 |
| Purity/Analysis Method | >95.0%(HPLC) |
| M.F. / M.W. | C__2__7H__2__9NO__1__1·HCl = 579.98 |
| 물리적 상태 (20 ℃) | Solid |
| 보관 조건 | Refrigerated (0-10°C) |
| 피해야 할 조건 | Light Sensitive,Heat Sensitive |
| 용기 | 100MG-Glass Bottle with Plastic Insert (이미지 보기), 25MG-Glass Bottle with Plastic Insert (이미지 보기) |
| CAS RN | 25316-40-9 |
| 관련 CAS RN | 23214-92-8 |
| Reaxys-RN | 4229251 |
| PubChem Substance ID | 253660149 |
| Merck Index (14) | 3439 |
| MDL 번호 | MFCD00077757 |
규격표
| Appearance | Light yellow to Brown powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Specific rotation | +240 to +270 deg(C=0.1,MeOH) |
물성치(참고치)
| 비율 광학 회전 [α]D | 248° (C=0.1,MeOH) |
| Maximum Wavelength | 497 nm (H__2O) |
| Solubility in water | Soluble |
| 용해성 (용해) | Tetrahydrofuran, Methanol |
| 용해도 (불용성) | Ether, Chloroform, Benzene, Acetone |
GHS
| 픽토그램 |
|
| 신호 워드 | Warning |
| 위험물 및 유해 등록 | H302 : Harmful if swallowed. H361 : Suspected of damaging fertility or the unborn child. H373 : May cause damage to organs through prolonged or repeated exposure. H351 : Suspected of causing cancer. |
| 주의 사항 | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P405 : Store locked up. |
법규 정보
| RTECS # | QI9295900 |
운송 정보
| HS 번호* | 2941.90-000 |
Application
Mitochondria research
Reference
- Mitochondrial proliferation during apoptosis induced by anticancer agents: effects of doxorubicin and mitoxantrone on cancer and cardiac cells
Application
Adeno-associated virus vector transduction enhancer
Doxorubicin increases transduction by adeno-associated virus (AAV) vectors.1-3)
References
- 1) Doxorubicin augments rAAV-2 transduction in rat neuronal cells
- 2) Dual therapeutic utility of proteasome modulating agents for pharmaco-gene therapy of the cystic fibrosis airway
- 3) Distinct classes of proteasome-modulating agents cooperatively augment recombinant adeno-associated virus type 2 and type 5-mediated transduction from the apical surfaces of human airway epithelia
Application
Reagent for nephritis (glomerulonephritis) model
References
- Adriamycin-induced nephrotic syndrome in rats: sequence of pathologic events
- T. Bertani, A. Poggi, R. Pozzoni, F. Delaini, G. Sacchi, Y. Thoua, G. Mecca, G. Remuzzi, M. B. Donati, Lab. Invest. 1982, 46, 16.
- Adriamycin-induced chronic proteinuria: a structural and functional study
- M. P. O'Donnell, L. Michels, B. Kasiske, L. Raij, W. F. Keane, J. Lab. Clin. Med. 1985 106, 62.
- Effect of dietary protein restriction on renal purines and purine-metabolizing enzymes in adriamycin nephrosis in rats: a mechanism for protection against acute proteinuria involving xanthine oxidase inhibition
- G. M. Ghiggeri, F. Ginevri, G. Cercignani, R. Oleggini, A. Garberi, G. Candiano, P. Altieri, R. Gusmano, Clin. Sci. (Lond). 1990, 79, 647.
- Effect of enalapril on adriamycin-induced nephrosis
- Erlotinib preserves renal function and prevents salt retention in doxorubicin treated nephrotic rats
- Protective effects of sinomenine against doxorubicin-induced nephrosis in rats
Application
Reagent for cardiomyopathy model
References
- Adriamycin-induced cardiac damage in the mouse: a small-animal model of cardiotoxicity
- S. H. Rosenoff, H. M. Olson, D. M. Young, F. Bostick, R. C. Young, J. Natl. Cancer Inst. 1975, 55, 191.
- Experimental animal models of adriamycin cardiotoxicity
- J. H. Doroshow, G. Y. Locker, C. E. Myers, Cancer Treat. Rep. 1979, 63, 855.
- Adriamycin-induced cardiomyopathy. A rat model
- A. Czarnecki, A. Hinek, D. Sołtysiak-Pawluczuk, Pol. J. Pharmacol. Pharm. 1986, 38, 171.
- Chronic doxorubicin induced cardiomyopathy in rabbits: mechanical, intracellular action potential, and beta adrenergic characteristics of the failing myocardium
- Serial assessment of myocardial properties using cyclic variation of integrated backscatter in an adriamycin-induced cardiomyopathy rat model
- Improvement of doxorubicin induced cardiomyopathy in rats treated with insulin-like growth factor I
- Intracoronary infusion of skeletal myoblasts improves cardiac function in doxorubicin-induced heart failure
- Doxorubicin dose for congestive heart failure modeling and the use of general ultrasound equipment for evaluation in rats Longitudinal in vivo study.
Application
Reagent for nausea or vomiting model
Reference
- The antiemetic effect of a novel tropisetron patch in anticancer agents-induced kaolin pica model using rats
Application
Reviews on an Anti-tumor Anthracycline Antibiotic, Doxorubicin
Doxorubicin is a widely used anti-tumor anthracycline antibiotic which exhibits good activity against a wide range of tumors. Doxorubicin interacts with DNA by intercalation and inhibition of DNA replication.
References
- A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics Adriamycin and daunorubicin
- Anthracyclines: Molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity
- The Power and Potential of Doxorubicin-DNA Adducts
- Pharmacokinetics of pegylated liposomal doxorubicin: review of animal and human studies
- Albumin as a drug carrier: Design of prodrugs, drug conjugates and nanoparticles
PubMed Literature
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