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CAS RN: 15663-27-1 | 제품번호: D3371
cis-Diammineplatinum(II) Dichloride
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•본 제품의 재고는 일본 본사의 재고입니다. 주문시, 5일안에 실험실까지 도착됩니다.
•본건의 원가격은 한국 대리점의 예상 판매가격입니다.자세한 정보가 필요하시면 연락해 주십시오.( SEJIN CI Co., Ltd. (한국총대리점) 전화 : 02-2655-2480 이메일 : sales@sejinci.co.kr)
•보관 조건은 예고없이 변경 될 수 있습니다. 제품 보관 조건의 최신 자료는 홈페이지에 기재되어 있으니 양해 부탁드립니다.
•본건의 원가격은 한국 대리점의 예상 판매가격입니다.자세한 정보가 필요하시면 연락해 주십시오.( SEJIN CI Co., Ltd. (한국총대리점) 전화 : 02-2655-2480 이메일 : sales@sejinci.co.kr)
•보관 조건은 예고없이 변경 될 수 있습니다. 제품 보관 조건의 최신 자료는 홈페이지에 기재되어 있으니 양해 부탁드립니다.
| 제품번호 | D3371 |
| M.F. / M.W. | H__6Cl__2N__2Pt = 300.05 |
| 물리적 상태 (20 ℃) | Solid |
| 보관 조건 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 불활성 가스 하에서 보관 | Store under inert gas |
| 피해야 할 조건 | Moisture Sensitive |
| 용기 | 100MG-Glass Bottle with Plastic Insert (이미지 보기), 1G-Glass Bottle with Plastic Insert (이미지 보기) |
| CAS RN | 15663-27-1 |
| PubChem Substance ID | 87558796 |
| Merck Index (14) | 2317 |
규격표
| Appearance | Light orange to Yellow to Green powder to crystal |
| Elemental analysis(Nitrogen) | 8.90 to 9.80 % |
물성치(참고치)
| mp | 270 °C |
| Degree of solubility in water | 2,530 mg/l 25 °C |
| 용해성 (용해) | Dimethylformamide |
GHS
| 픽토그램 |
|
| 신호 워드 | Danger |
| 위험물 및 유해 등록 | H300 : Fatal if swallowed. H319 : Causes serious eye irritation. H360 : May damage fertility or the unborn child. H362 : May cause harm to breast-fed children. H370 : Causes damage to organs. H372 : Causes damage to organs through prolonged or repeated exposure. H340 : May cause genetic defects. H350 : May cause cancer. |
| 주의 사항 | P501 : Dispose of contents/ container to an approved waste disposal plant. P263 : Avoid contact during pregnancy/ while nursing. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
법규 정보
| RTECS # | TP2450000 |
운송 정보
| UN 번호 | UN3288 |
| 등급 | 6.1 |
| 포장 그룹 | II |
| HS 번호* | 2843.90-000 |
Application
Quorum sensing inhibitor
Reference
- The Role of Drug Repurposing in the Development of Novel Antimicrobial Drugs: Non-Antibiotic Pharmacological Agents as Quorum Sensing-Inhibitors
Application
Platinum Coordination Complexes as Antitumor Agents
The development of platinum coordination complexes as antitumor agents began in the 1960s, and the highest antitumor activity was exhibited by cisplatin, approved by FDA in 1978. Improved versions carboplatin [C2043] and oxaliplatin [O0372] were developed to avoid the serious side effects and the problem with resistance associated with the use of cisplatin.1-5)
The platinum complexes diffuse to the tumor cell, where they undergo hydrolysis displacement of their one chloride or carboxylate group leading to a platinum cation. The resulting cation coordinates to the guanine N7-position of DNA give a coordination cation. Then, intrastrand cross-linking occurs to anther guanine via further hydrolysis displacement of the remaining chloride or carboxylate. The forming [Pt(NH2R)2]2+ ― DNA complex distort the DNA helix (Fig. 1 and 2)6). Thus, DNA duplication is hindered, which ultimately triggers tumor cell apoptosis.3)
The platinum complexes diffuse to the tumor cell, where they undergo hydrolysis displacement of their one chloride or carboxylate group leading to a platinum cation. The resulting cation coordinates to the guanine N7-position of DNA give a coordination cation. Then, intrastrand cross-linking occurs to anther guanine via further hydrolysis displacement of the remaining chloride or carboxylate. The forming [Pt(NH2R)2]2+ ― DNA complex distort the DNA helix (Fig. 1 and 2)6). Thus, DNA duplication is hindered, which ultimately triggers tumor cell apoptosis.3)
References
- 1)G. Mathe, Y. Kidani, M. Segiguchi, M. Eriguchi, G. Fredj, G. Peytavin, J. L. Misset, S. Brienza, F. de Vassals, E. Chenu, C. Bourut, Biomed. Pharmacother. 1989, 43, 237.
- 2)L. R. Kelland, S. Y. Sharp, C. F. O’Neill, F. I. Raynaud, P. J. Beale, I. R. Judson, J. Inorg. Biochem. 1999, 77, 111.
- 3)D. Wang, S. J. Lippard, Nat. Rev. Drug Discov. 2005, 4, 307.
- 4)S. Trzaska, Chem. Eng. News 2005, 83, 3.
- 5)L. P. Martin, T. C. Hamilton, R. J. Schilder, Clin. Cancer Res. 2008, 14, 1291.
- 6)A. Gelasco, S. J. Lippard, Biochemistry, 1998, 37, 9230.
Application
Reagent for renal failure model
References
- Cis-diamminedichloroplatinum (DDP) induced acute renal failure (ARF): attempts at amelioration
- S. Chopra, J. Kaufman, W. Flamenbaum, Clin. Exp. Dial. Apheresis. 1983, 7, 25.
- Cis-diamminedichloroplatinum (II)-induced acute renal failure in the rat: enzyme histochemical studies
- Cis-diamminedichloroplatinum (II)-induced acute renal failure in the rat. Correlation of structural and functional alterations
- T. W. Jones, S. Chopra, J. S. Kaufman, W. Flamenbaum, B. F. Trump, Lab. Invest. 1985, 52, 363.
- Protective effects of dithiocarbamates against renal toxicity of cis-diamminedichloroplatinum in rats
- Celecoxib, a selective cyclooxygenase-2 inhibitor, attenuates renal injury in a rat model of Cisplatin-induced nephrotoxicity
- Effect of fructose-1,6-bisphosphate on the nephrotoxicity induced by cisplatin in rats
- Reduction of oxidative stress may play a role in the anti-inflammatory effect of the novel herbal formulation in a rat model of hydrochloric acid-induced cystitis
Application
Reagent for nausea or vomiting model
References
- Cisplatin-induced emesis in the Ferret: a new animal model.
- A. P. Florczyk, J. E. Schurig, W. T. Bradner, Cancer Treat Rep. 1982, 66, 1, 187-189.
- The anti-cancer drug-induced pica in rats is related to their clinical emetogenic potential.
Application
Reviews on the Biochemical Mechanisms of Action of Cisplatin
References
- Structure, recognition, and processing of cisplatin-DNA adducts
- Why does cisplatin reach guanine-N7 with competing S-donor ligands available in the cell?
- Biochemical modulation of cisplatin mechanisms of action: enhancement of antitumor activity and circumvention of drug resistance
- Cisplatin: mode of cytotoxic action and molecular basis of resistance
- Cellular responses to cisplatin. The roles of DNA-binding proteins and DNA repair.
- G. Chu. J. Biol. Chem. 1994, 269, 787.
- Cellular processing of platinum anticancer drugs
PubMed Literature
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