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CAS RN: 77-48-5 | 제품번호: D1265
1,3-Dibromo-5,5-dimethylhydantoin
•본 제품의 재고는 일본 본사의 재고입니다. 주문시, 5일안에 실험실까지 도착됩니다.
•본건의 원가격은 한국 대리점의 예상 판매가격입니다.자세한 정보가 필요하시면 연락해 주십시오.( SEJIN CI Co., Ltd. (한국총대리점) 전화 : 02-2655-2480 이메일 : sales@sejinci.co.kr)
•보관 조건은 예고없이 변경 될 수 있습니다. 제품 보관 조건의 최신 자료는 홈페이지에 기재되어 있으니 양해 부탁드립니다.
•본건의 원가격은 한국 대리점의 예상 판매가격입니다.자세한 정보가 필요하시면 연락해 주십시오.( SEJIN CI Co., Ltd. (한국총대리점) 전화 : 02-2655-2480 이메일 : sales@sejinci.co.kr)
•보관 조건은 예고없이 변경 될 수 있습니다. 제품 보관 조건의 최신 자료는 홈페이지에 기재되어 있으니 양해 부탁드립니다.
제품번호 | D1265 |
Purity/Analysis Method | >97.0%(T) |
M.F. / M.W. | C__5H__6Br__2N__2O__2 = 285.92 |
물리적 상태 (20 ℃) | Solid |
보관 조건 | Room Temperature (Recommended in a cool and dark place, <15°C) |
불활성 가스 하에서 보관 | Store under inert gas |
피해야 할 조건 | Moisture Sensitive |
CAS RN | 77-48-5 |
Reaxys-RN | 146024 |
PubChem Substance ID | 87567800 |
SDBS | 4013 |
Merck Index (14) | 3017 |
MDL 번호 | MFCD00003189 |
규격표
Appearance | White to Light yellow to Light orange powder to crystal |
Purity(Iodometric Titration) | min. 97.0 % |
Solubility in hot Toluene | almost transparency |
물성치(참고치)
mp | 193 °C |
bp | 376 °C |
용해성 (용해) | Chloroform, Ethanol |
GHS
픽토그램 | |
신호 워드 | Danger |
위험물 및 유해 등록 | H301 : Toxic if swallowed. H314 : Causes severe skin burns and eye damage. H410 : Very toxic to aquatic life with long lasting effects. H272 : May intensify fire; oxidizer. |
주의 사항 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P260 : Do not breathe dusts or mists. P270 : Do not eat, drink or smoke when using this product. P220 : Keep/Store away from clothing/ combustible materials. P210 : Keep away from heat. P221 : Take any precaution to avoid mixing with combustibles. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P370 + P378 : In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish. P391 : Collect spillage. P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower. P301 + P330 + P331 : IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P363 : Wash contaminated clothing before reuse. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor. P405 : Store locked up. |
법규 정보
RTECS # | MU0686000 |
운송 정보
UN 번호 | UN3087 |
등급 | 5.1 / 6.1 |
포장 그룹 | II |
HS 번호* | 2933.21-000 |
Application
Carbon-Heteroatom Bond Formation at the Benzylic Position of Methylarenes
Typical procedure (Ar = 4-BrPh, nucleophile = PhCO2H): To a solution of 4-bromotoluene (342.1 mg, 2.0 mmol) in anhydrous MeCN (4 mL) are added 1,3-dibromo-5,5-dimethylhydantoin (314.5 mg, 1.1 mmol) and AIBN (16.8 mg, 0.1 mmol) at room temperature. The mixture is stirred for 2 h at 90 °C. Then, benzoic acid (268.7 mg, 2.2 mmol) and DIPEA (0.35 mL, 2.0 mmol) are added at room temperature and the mixture is stirred for 16 h at 90 °C. The mixture is quenched by the addition of saturated aq. Na2SO3 solution (10 mL) and then extracted with CHCl3 (3 × 20 mL). The organic layer is dried over Na2SO4. After removal of the solvent under reduced pressure, the residue is purified by column chromatography on silica gel (eluent: hexane/CHCl3 = 1/1) to afford 4-bromobenzyl benzoate as a white solid. (489.1 mg, 84% yield).
References
Application
Selective ortho-Monobromination of Phenols and Polyphenols
Typical Procedure:
DBDMH (0.50–0.53 eq.) is added in part into the solution of starting material in CHCl3 (5–7 mL / mmol) at room temperature. Upon addition of the DBDMH, the solution becomes red or deep brown colored, the next portion of DBDMH is added after the disappearance of color and so on. The progress of the reaction is monitored by GC-MS. After completion of the reaction, removal of the solvent followed by the separation of the solid byproduct (derived from DBDMH) by simple filtration provides the almost pure bromide. 10% Aqueous sodium hydrosulfite solution is added into the reaction mixture, stirred for 5 min. Organic layer is separated, dried over MgSO4 and concentrated in evaporator yields the almost pure product. Passing through a small chromatographic column, it gives the pure products.
DBDMH (0.50–0.53 eq.) is added in part into the solution of starting material in CHCl3 (5–7 mL / mmol) at room temperature. Upon addition of the DBDMH, the solution becomes red or deep brown colored, the next portion of DBDMH is added after the disappearance of color and so on. The progress of the reaction is monitored by GC-MS. After completion of the reaction, removal of the solvent followed by the separation of the solid byproduct (derived from DBDMH) by simple filtration provides the almost pure bromide. 10% Aqueous sodium hydrosulfite solution is added into the reaction mixture, stirred for 5 min. Organic layer is separated, dried over MgSO4 and concentrated in evaporator yields the almost pure product. Passing through a small chromatographic column, it gives the pure products.
References
- 1,3-Dibromo-5,5-dimethylhydantoin, a useful reagent for ortho-monobromination of phenols and polyphenols
- A. Alam, Y. Takaguchi, S. Tsuboi, J. Fac. Environ. Sci. Tech., Okayama Univ. 2005, 10, 105.
PubMed Literature
기사 / 브로셔
TCIMail
[Research Articles] Carbon-Heteroatom Bond Formation at the Benzylic Position of Methylarenes제품문서 (분석 차트를 제공하지 못할 수도 있으니 양해 바랍니다.)
SDS
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