Maintenance Notice (3:15 AM - 2:55 PM May 24, 2025 UTC): This website is scheduled to be unavailable due to maintenance. We appreciate your patience and understanding.
Product Document Searching Made Easy by 2D Code! | TCI Materials Science News May 2025 | [Product Highlights] Endogenous Biotin-Blocking Reagent... | Various analytical charts can be searched on each product detail page and Product Document Search (The kinds of analytical charts differ by product)
Maximum quantity allowed is 999
Please select the quantity
Gilman Reaction
Gilman reaction is a name reaction as typified by 1,4-additions of α,β-unsaturated ketones as well as SN2-type alkylation of alkyl halides. Gilman reagents are organocopper compounds typically illustrated by C-Cu-C core with a lithium counterion and are particularly useful for the Gilman reaction. The reagents are readily preparable from 2 equiv. of alkyllithium reagents and a copper(I) salt such as CuI.
- Reagents:
- Gilman reagents
- Reactants:
- α,β-Unsaturated carbonyl compounds, Alkyl halides
- Products:
- Corresponding adducts
- Scheme:
-
- Original literature:
-
- The Preparation of Methylcopper and some Observations on the Decomposition of Organocopper Compounds
- Review literature:
-
- Henry Gilman: American Pioneer in the Rise of Organometallic Chemistry in Modern Science and Technology
