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CAS RN: 211555-04-3 | Product Number: W0013
WHI-P154
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Purity: >98.0%(HPLC)
Synonyms:
- 2-Bromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]phenol
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 10MG |
₩194,300
|
5 | ≥40 | Contact Us | |
| 50MG |
₩704,900
|
8 | 34 | Contact Us |
* Please contact our distributor of SEJIN CI Co., Ltd.
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:
sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
| Product Number | W0013 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__6H__1__4BrN__3O__3 = 376.21 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 211555-04-3 |
| Reaxys Registry Number | 8787580 |
| PubChem Substance ID | 468593122 |
| MDL Number | MFCD02179366 |
Specifications
| Appearance | White to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 228.0 to 232.0 °C |
| Elemental analysis(Nitrogen) | 10.50 to 11.50 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 230 °C |
| Maximum Absorption Wavelength | 335(MeOH) nm |
GHS
| Hazard Statements | H413 : May cause long lasting harmful effects to aquatic life. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. |
Related Laws:
Transport Information:
| H.S.code* | 2933.59-000 |
Application
WHI-P 154: A Potent Janus-Associated Kinase 3 (JAK3) Inhibitor
WHI-P 154 is a potent Janus-associated kinase 3 (JAK3) inhibitor that displays no activity at JAK1 or JAK2. JAK3 is a cytoplasmic protein tyrosine kinase that functions in the initiation of cytokine-triggered signal transduction by catalyzing the phosphorylation of signal transduction and activators of transcription (STAT). The phosphorylated SATAs are translocated to the nucleus to activate target genes. WHI-P 154 is cytotoxic human glioblastoma cells. Recent reports have indicated that JAK3 is expressed in lymphoid cells and is involved in the signaling of T cell functions. Therefore, the development of a selective JAK3 inhibitor has been shown to have a potential benefit in the treatment of autoimmune disorders. (The product is for research purpose only.)
References
- 4-(3'-Bromo-4'hydroxylphenyl)-amino-6,7-dimethoxyquinazoline: a novel quinazoline derivative with potent cytotoxic activity against human glioblastoma cells
- Inhibition of ALK enzymatic activity in T-cell lymphoma cells induces apoptosis and suppresses proliferation and STAT3 phosphorylation independently of Jak3
- The specificity of JAK3 kinase inhibitors
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