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CAS RN: 62996-74-1 | Product Number: T4000
Staurosporine
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Purity: >98.0%(HPLC)
Synonyms:
- (5S,6R,7R,9S)-6-Methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-5H,14H-17-oxa-4b,9a,15-triaza-5,9-methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-14-one
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 10MG |
₩260,900
|
29 | 36 | Contact Us |
* Please contact our distributor of SEJIN CI Co., Ltd.
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:
sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
| Product Number | T4000 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__8H__2__6N__4O__3 = 466.54 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| Packaging and Container | 10MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 62996-74-1 |
| Reaxys Registry Number | 6674025 |
| PubChem Substance ID | 468593064 |
| MDL Number | MFCD18252446 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation | +71.0 to +75.0 deg(C=0.1, ﾒﾀﾉｰﾙ) |
| NMR | confirm to structure |
Properties (reference)
GHS
| Hazard Statements | H413 : May cause long lasting harmful effects to aquatic life. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. |
Related Laws:
| RTECS# | KC6550000 |
Transport Information:
| H.S.code* | 2941.90-000 |
Application
Staurosporine: A Potent Inhibitor of Protein Kinase
Staurosporine (AM-2282) is an indolocarbazole antibiotic originally isolated from the bacterium Streptomyces staurosporeus by Omura et al. in 1977.1) It has been reported that staurosporine and display strong inhibitory effect against a variety of kinases including protein kinase C (PKC), and a number of biological properties such as antifungal, antibacterial, and apoptosis-inducing activities1,2). Staurosporine also inhibits wild-type LRRK2 (leucine-rich repeat kinase 2), which is a large protein (2527 amino acids) with serine-threonine (Ser/Thr) protein kinase activity and autophosphorylation activity.3) Nevertheless, staurosporine is poorly selective against other protein kinases. To obtain specific PKC inhibitors, a number of its analogues has been developed.4,5) (The product is for research purpose only.)
References
- 1) Staurosporine, a Potentially Important Gift from a Microorganism (a review)
- 2) Induction of a common pathway of apoptosis by staurosporine
- 3) Identification of compounds that inhibit the kinase activity of leucine-rich repeat kinase 2
- 4) Chemical biology of natural indolocarbazole products: 30 years since the discovery of staurosporine (a review)
- 5) Protein kinase inhibition of clinically important staurosporine analogues (a review)
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