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CAS RN: 173903-47-4 | Product Number: T3862
Tizoxanide
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Purity: >95.0%(HPLC)
Synonyms:
- 2-Hydroxy-N-(5-nitro-2-thiazolyl)benzamide
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 25MG |
₩510,600
|
18 | 15 | It can be shipped in about 3-4 weeks after ordering | |
| 100MG |
₩1,528,100
|
22 | 0 | It can be shipped in about 3-4 weeks after ordering |
* Please contact our distributor of SEJIN CI Co., Ltd.
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:
sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
Supplemental Product Information:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| Product Number | T3862 |
| Purity / Analysis Method | >95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__0H__7N__3O__4S = 265.24 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 25MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 173903-47-4 |
| Reaxys Registry Number | 8324260 |
| PubChem Substance ID | 468592989 |
| MDL Number | MFCD07484970 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Elemental analysis(Nitrogen) | 15.10 to 16.60 % |
Properties (reference)
| Melting Point | 254 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
Transport Information:
| H.S.code* | 2934.10-000 |
Application
Tizoxanide: An Active Metabolite of Nitazoxanide, a Thiazolide Antiprotozoal and Antiviral Agent
Tizoxanide is an active metabolite of nitazoxanide [N1031] which is originally developed as a thiazolide antiprotozoal agent that shows excellent in vitro activity against a variety of microorganisms, including a broad range of protozoa and helminths.1,2) Following oral administration in animals, nitazoxanide is rapidly hydrolyzed to tizoxanide (desacetyl-nitazoxanide) by esterase. The antiprotozoal activity of tizoxanide is believed to be due to interference with the pyruvate:ferredoxin oxidoreductase (PFOR) enzyme-dependent electron transfer reaction which is essential to anaerobic energy metabolism. Recently, antiviral activity of nitazoxanide (tizoxanide) against a broad range of other RNA and DNA viruses such as hepatitis B virus, hepatitis C virus and influenza virus has been recognized in in vitro systems.3-5) Nitazoxanide (tizoxanide) is synergistic with neuraminidase inhibitors, and also inhibits the replication of a broad range of viruses. (The product is for research purpose only.)
References
- 1) In vitro evaluation of activities of nitazoxanide and tizoxanide against anaerobes and aerobic organisms
- 2) In vitro activity of nitazoxanide and related compounds against isolates of Giardia intestinalis, Entamoeba histolytica and Trichomonas vaginalis
- 3) Nitazoxanide, tizoxanide and other thiazolides are potent inhibitors of hepatitis B virus and hepatitis C virus replication
- 4) Thiazolides, a new class of anti-influenza molecules targeting viral hemagglutinin at the post-translational level
- 5) Antiviral activity of substituted salicylanilides - a review
Application
Tizoxanide: An Active Metabolite of Antiprotozoal Nitazoxanide
Tizoxanide is an active metabolite of nitazoxanide [N1031] which is a thiazolide antiprotozoal agent. The antiprotozoal activity of tizoxanide is believed to be due to interference with the pyruvate:ferredoxin oxidoreductase (PFOR) enzyme-dependent electron transfer reaction which is essential to anaerobic energy metabolism. (The product is for research purpose only.)
References
- Nitazoxanide: pharmacokinetics and metabolism in man
- The pharmacokinetics of nitazoxanide active metabolite (tizoxanide) in goats and its protein binding ability in vitro
- Validated and Optimized High-Performance Liquid Chromatographic Determination of Tizoxanide, the Main Active Metabolite of Nitazoxanide in Human Urine, Plasma and Breast Milk
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Specifications
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