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CAS RN: 10537-47-0 | Product Number: T3667
Tyrphostin A9
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Purity: >98.0%(GC)
Synonyms:
- Malonoben
- [4-Hydroxy-3,5-bis(2-methyl-2-propanyl)benzylidene]malononitrile
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 25MG |
₩126,800
|
5 | 0 | Contact Us | |
| 100MG |
₩374,400
|
10 | 3 | Contact Us |
* Please contact our distributor of SEJIN CI Co., Ltd.
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:
sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
| Product Number | T3667 |
| Purity / Analysis Method | >98.0%(GC) |
| Molecular Formula / Molecular Weight | C__1__8H__2__2N__2O = 282.39 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 25MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 10537-47-0 |
| Reaxys Registry Number | 2700764 |
| PubChem Substance ID | 468592884 |
| MDL Number | MFCD00209853 |
Specifications
| Appearance | Light orange to Yellow to Green powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 139.0 to 147.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 140 °C |
| Maximum Absorption Wavelength | 464 nm (EtOH) |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 + H311 + H331 : Toxic if swallowed, in contact with skin or if inhaled. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P361 + P364 : Take off immediately all contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P311 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P405 : Store locked up. |
Related Laws:
| RTECS# | OO3737000 |
Transport Information:
| UN Number | UN3439 |
| Class | 6.1 |
| Packing Group | III |
| H.S.code* | 2926.90-000 |
Application
Type IV secretion system (T4SS) research
Reference
- Chemical Genetics Reveals Bacterial and Host Cell Functions Critical for Type IV Effector Translocation by Legionella pneumophila
Application
Tyrphostin A9: A Tyrosine Kinase Inhibitor
Tyrphostin A9 (other names in the references: Malonoben, Tyrphostin AG17 or SF6847) is a tyrosine kinase inhibitor originally synthesized as a potential anticarcinogenic compound. Reportedly, tyrphostin A9 selectively inhibits the activity of a platelet-derived growth factor receptor (PDGFR) protein1), the growth of vascular smooth muscle cells1), the growth of cancer cells2,3), and the phosphorylation of tyrosine1,2,4,5).
References
- 1)Tyrphostins inhibit PDGF-induced DNA synthesis and associated early events in smooth muscle cells
- 2)STAT3 is essential for Hodgkin lymphoma cell proliferation and is a target of tyrphostin AG17 which confers sensitization for apoptosis
- 3)Tyrphostin AG17, [(3,5-Di-tert-butyl-4-hydroxybenzylidene)-malononitrile], inhibits cell growth by disrupting mitochondria
- 4)Role of the tyrosine kinase pyk2 in the integrin-dependent activation of human neutrophils by TNF
- 5)Tyrphostin A9 inhibits calcium release-dependent phosphorylations and calcium entry via calcium release-activated channel in Jurkat T cells
Articles/Brochures
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