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CAS RN: 54965-24-1 | Product Number: T2510
Tamoxifen Citrate
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Purity: >98.0%(T)(HPLC)
Synonyms:
- (Z)-1-(4-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene Citrate
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
₩190,600
|
39 | 0 | It can be shipped in about 3-4 weeks after ordering | |
| 5G |
₩664,200
|
1 | 21 | It can be shipped in about 3-4 weeks after ordering |
* Please contact our distributor of SEJIN CI Co., Ltd.
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:
sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
| Product Number | T2510 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__6H__2__9NO·C__6H__8O__7 = 563.65 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Hygroscopic,Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 54965-24-1 |
| Related CAS RN | 10540-29-1 |
| Reaxys Registry Number | 8888650 |
| PubChem Substance ID | 87560062 |
| Merck Index (14) | 9048 |
| MDL Number | MFCD00058321 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
Properties (reference)
| Melting Point | 142 °C(dec.) |
| Solubility in water | Slightly soluble |
| Solubility (soluble in) | Ethanol, Acetone, Methanol |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H302 : Harmful if swallowed. H360 : May damage fertility or the unborn child. H362 : May cause harm to breast-fed children. H350 : May cause cancer. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P263 : Avoid contact during pregnancy/ while nursing. P260 : Do not breathe dusts or mists. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | KH2387000 |
Transport Information:
| H.S.code* | 2921.49-000 |
Application
Tamoxifen Citrate: Selective Estrogen Receptor Modulator (SERM)
Tamoxifen citrate is a widely used nonsteroidal anti-estrogen agent for the treatment of hormone-dependent breast cancer. Tamoxifen is a prodrug and extensively metabolized by cytochrome P450 (CYP450) enzymes into active metabolites including 4-hydroxytamoxifen [H1693] and endoxifen (4-hydroxy-N-desmethyltamoxifen). Each acts as an estrogen receptor antagonist in breast tissue. Tamoxifen is commonly referred to as a selective estrogen receptor modulator (SERM), since it behaves as an estrogen receptor agonist in other tissues. (The product is for research purpose only.)
References
- Tamoxifen in the treatment of breast cancer
- Tamoxifen, raloxifene, and the prevention of breast cancer
- Mechanisms of tamoxifen-induced apoptosis
- Mechanisms of tamoxifen resistance
- CYP2D6 and tamoxifen: DNA matters in breast cancer
Application
Tamoxifen Citrate: Selective Estrogen Receptor Modulator (SERM)
Tamoxifen citrate is a widely used nonsteroidal anti-estrogen agent for the treatment of hormone-dependent breast cancer. Tamoxifen is a prodrug and extensively metabolized by cytochrome P450 (CYP450) enzymes into active metabolites including 4-hydroxytamoxifen and endoxifen (4-hydroxy-N-desmethyltamoxifen). They act as an estrogen receptor antagonist in breast tissue. Tamoxifen is commonly referred to as a selective estrogen receptor modulator (SERM), since it behaves as an estrogen receptor agonist in other tissues. (The product is for research purpose only.)
References
- Tamoxifen in the treatment of breast cancer
- Tamoxifen, Raloxifene, and the Prevention of Breast Cancer
- Mechanisms of tamoxifen-induced apoptosis
- Mechanisms of tamoxifen resistance
- CYP2D6 and tamoxifen: DNA matters in breast cancer
PubMed Literature
Articles/Brochures
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