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CAS RN: 66-71-7 | Product Number: R0309

1,10-Phenanthroline (HPMC encapsulated)


Purity:
Synonyms:
Product Documents:
10EACH
₩101,800
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* The storage conditions are subject to change without notice.

Product Number R0309
Molecular Formula / Molecular Weight C__1__2H__8N__2 = 180.21 
Physical State (20 deg.C) Solid
Storage Temperature Room Temperature (Recommended in a cool and dark place, <15°C)
Store Under Inert Gas Store under inert gas
Condition to Avoid Hygroscopic
CAS RN 66-71-7
Specifications
Appearance White to Almost white capsule
Functionality test (conversion ratio) min.90.0 %
Properties (reference)
GHS
Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H301 : Toxic if swallowed.
H410 : Very toxic to aquatic life with long lasting effects.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P273 : Avoid release to the environment.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P391 : Collect spillage.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P405 : Store locked up.
Related Laws:
Transport Information:
UN Number UN2811
Class 6.1
Packing Group III
H.S.code* 3822.19-000
*This code is applied to the products when TCI exports from Japan and not for import in your country.
Application
"TCI Practical Example: Goldberg Amination Using Capsule Reagents (中文) "

TCI Practical Example: Goldberg Amination Using Capsule Reagents

Used Chemicals

Procedure

Copper(I) iodide (HPMC encapsulated) (one capsule) and 1,10-phenanthrolin (HPMC encapsulated) (one capsule) were added to a solution of indole (93.7 mg, 800 µmol), 2-bromopyridine (164 mg, 1.04 mmol, 1.3 eq.) and cesium carbonate (521 mg, 1.60 mmol, 2.0 eq.) in DMSO (2.5 mL) at r.t. and the reaction mixture was stirred at 150 °C for 2 hours. After cooling to r.t., the solution was diluted with ethyl acetate (15 mL) and sat. Na2SO4 aq. (15 mL), and filtered through Celite pad and the filtrate was extracted with ethyl acetate (15 mL x 2). The organic layer was washed with 2 mol/L HCl (15 mL) and sat. NaHCO3 aq. (15 mL), dried over sodium sulfate and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (ethyl acetate:hexane = 10:1 - 5:1) to afford N-(2-pyridyl)indole (130 mg, 84% yield) as a pale-yellow oil.

Experimenter’s Comments

The reaction mixture was monitored by UPLC.
The material of the capsule is water-soluble HPMC (hydroxypropyl methylcellulose).
he capsule has the shape shown in Fig. 1 and 1,10-phenanthrolin (ca. 200 μmol) and copper(I) iodide (ca. 800 μmol) are encapsulated in each capsule, respectively.

Appearance of capsule
Fig. 1 Appearance of capsule

The capsules dissolves in water or polar solvents as shown in Fig. 2.
Capsule disintegrating
Fig. 2 Capsule disintegrating
(left) Just after the capsule is put in, (right) 15 minutes after the capsule is put in

Analytical Data

N-(2-Pyridyl)-indole

1H NMR (400 MHz, CDCl3); δ 8.21 (d, 1H, J = 8.0 Hz), 7.85-7.81 (m, 1H), 7.37 (d, 1H, J = 4.0 Hz), 7.67 (d, 1H, J = 8.0 Hz), 7.51 (d, 1H, J = 8.0 Hz), 7.30(t, 1H, J = 8.0 Hz), 7.23-7.16 (m, 2H).

Lead Reference

Other References


Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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Other Documents

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