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CAS RN: 59-33-6 | Product Number: P2369
Pyrilamine Maleate
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Purity: >98.0%(T)(HPLC)
Synonyms:
- Mepyramine Maleate
- N-(4-Methoxyphenyl)methyl-N',N'-dimethyl-N-(2-pyridinyl)-1,2-ethanediamine Maleate
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 5G |
₩88,800
|
14 | 20 | Contact Us | |
| 25G |
₩299,700
|
3 | 0 | It can be shipped in about 2 weeks after ordering |
* Please contact our distributor of SEJIN CI Co., Ltd.
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:
sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
| Product Number | P2369 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__7H__2__3N__3O·C__4H__4O__4 = 401.46 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Condition to Avoid | Light Sensitive |
| CAS RN | 59-33-6 |
| Related CAS RN | 91-84-9 |
| Reaxys Registry Number | 3836479 |
| PubChem Substance ID | 354333684 |
| Merck Index (14) | 7984 |
| MDL Number | MFCD00069333 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 %(total of Ion-Pair) |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 100.0 to 104.0 °C |
Properties (reference)
| Melting Point | 102 °C |
| Maximum Absorption Wavelength | 310(EtOH) nm |
| Solubility in water | Soluble |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | UT1225000 |
Transport Information:
| H.S.code* | 2933.39-000 |
Application
Pyrilamine Maleate: A First Generation Histamine H1 Receptor Antagonist
Pyrilamine maleate, also known as pyrilamine maleate, is a first generation histamine H1 receptor antagonist. Pyrilamine binds to a G protein-coupled form of the receptor and promotes a G protein-coupled inactive state of the H1 receptor that interferes with the Gq/11-mediated signaling. Pyrilamine permeates the blood-brain barrier causing drowsiness. Pyrilamine also has anticholinergic properties. For reference, we also have related first generation histamine H1 receptor antagonists, such as pheniramine maleate [P2271], chlorpheniramine maleate [C0873] and bromopheniramine maleate [B5167]. (The product is for research purpose only.)
References
- Physical and biological properties of pyrilamine (a review)
- Histaminergic systems and sleep. Studies in man with H1 and H2 antagonists
- Influence of certain H1-blockers on the step-through active avoidance response in rats
- Mepyramine, a Histamine H1 Receptor Inverse Agonist, Binds Preferentially to a G Protein-coupled Form of the Receptor and Sequesters G Protein
- Delineation of receptor-ligand interactions at the human histamine H1 receptor by a combined approach of site- directed mutagenesis and computational techniques - or - how to bind the H1 receptor (a review)
- Simultaneous determination of pseudoephedrine, pheniramine, guaifenesin, pyrilamine, chlorpheniramine and dextromethorphan in cough and cold medicines by high performance liquid chromatography
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