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CAS RN: 105816-04-4 | Product Number: N0912
Nateglinide
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Purity: >98.0%(T)(HPLC)
Synonyms:
- N-[(trans-4-Isopropylcyclohexyl)carbonyl]-D-phenylalanine
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 500MG |
₩109,200
|
4 | 19 | Contact Us | |
| 1G |
₩193,100
|
14 | 4 | Contact Us | |
| 5G |
₩487,500
|
1 | 0 | Contact Us |
* Please contact our distributor of SEJIN CI Co., Ltd.
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:
sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
| Product Number | N0912 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__9H__2__7NO__3 = 317.43 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 500MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 105816-04-4 |
| Reaxys Registry Number | 6486870 |
| PubChem Substance ID | 160871031 |
| Merck Index (14) | 6428 |
| MDL Number | MFCD00875706 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Specific rotation [a]20/D | -36.5 to -40.0 deg(C=1, 0.1mol/L NaOH) |
Properties (reference)
| Specific Rotation | -38° (C=1,0.1mol/L NaHO sol.) |
| Solubility in water | Insoluble |
| Degree of solubility in water | 0.0066 g/l |
GHS
Related Laws:
| RTECS# | SQ7318950 |
Transport Information:
| H.S.code* | 2924.29-000 |
Application
速効性のATP感受性K+チャンネルアンタゴニスト，ナテグリニド
Nateglinide is a D-phenylalanine derivative which rapidly increases the release of insulin from pancreatic B-cells. More rapidly than that of sulfonylurea antidiabetics, nateglinide inhibits ATP-gated K+ channels and thereby causes depolarization of the B-cell membrane. The depolarization leads to activation of voltage-dependent Ca channels and Ca2+ influx into the B-cell, and eventually increases insulin release. (The product is for research purpose only.)
References
- Hypoglycaemic and insulinotropic effects of a novel oral antidiabetic agent, (－)-N-(trans-4-isopropylcyclohexane-carbonyl)-D-phenylalanine (A-4166)
- The effect of food on the oral bioavailability and the pharmacodynamic actions of the insulinotropic agent nateglinide in healthy subjects
- Pancreatic β-cell KATP channel activity and membrane-binding studies with nateglinide: a comparison with sulfonylureas and repaglinide
- Nateglinide (a review)
- Nateglinide quantification in rabbit plasma by HPLC: Optimization and application to pharmacokinetic study
- Development and validation of a stereoselective HPLC method for the determination of the in vitro transport of nateglinide enantiomers in rat intestine
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