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CAS RN: 13860-38-3 | Product Number: M3387

1-Methylpseudouridine


Purity: >99.0%(HPLC)
Synonyms:
  • 1-Methyl-5-β-D-ribofuranosyluracil
  • 1-Methyl-5-β-D-ribofuranosyl-2,4(1H,3H)-pyrimidinedione
  • (1S)-1,4-Anhydro-1-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)-D-ribitol
  • m1ψ
Product Documents:
100MG
₩421,800
13   1  
1G
₩1,346,800
20   Contact Us
* Please contact our distributor of SEJIN CI Co., Ltd. if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:  sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.

Product Number M3387
Purity / Analysis Method >99.0%(HPLC)
Molecular Formula / Molecular Weight C__1__0H__1__4N__2O__6 = 258.23 
Physical State (20 deg.C) Solid
Storage Temperature Refrigerated (0-10°C)
Store Under Inert Gas Store under inert gas
Condition to Avoid Air Sensitive,Heat Sensitive
Packaging and Container 100MG-Glass Bottle with Plastic Insert (View image),  1G-Glass Bottle with Plastic Insert (View image)
CAS RN 13860-38-3
Reaxys Registry Number 551569
MDL Number

MFCD10687017

Specifications
Appearance White to Light yellow powder to crystal
Purity(HPLC) min. 99.0 area%
Purity(qNMR) min. 98.0 %
Melting point 187.0 to 191.0 °C
Specific rotation -6.0 to -8.0 deg (C=1, water)
NMR confirm to structure
Properties (reference)
Melting Point 189 °C
GHS
Related Laws:
Transport Information:
H.S.code* 2934.99-000
*This code is applied to the products when TCI exports from Japan and not for import in your country.
Application
1-Methylpseudouridine (m1Ψ): A Non-Natural Pyrimidine Nucleoside Found in mRNA Vaccines

In recent years, numerous studies have demonstrated the outstanding abilities of mRNA to elicit potent immune, making it a viable new platform for vaccine development1). Additionally there are reports on incorporation of modified nucleobases into mRNA offering advantages for the generation of potent and long-lived antibody responses. In protein biosynthesis, 1-methylpseudouridine (m1Ψ) and pseudouridine (Ψ) [P2939 (synthetic)] [P2396] are read like uridine (U) and enable comparatively high protein yields. Furthermore, m1Ψ enhances immune evasion, protein production, and consequently vaccine efficacy.2-4)

References


PubMed Literature

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