Maximum quantity allowed is 999
Please select the quantity
CAS RN: 13860-38-3 | Product Number: M3387
1-Methylpseudouridine
Purity: >99.0%(HPLC)
Synonyms:
- 1-Methyl-5-β-D-ribofuranosyluracil
- 1-Methyl-5-β-D-ribofuranosyl-2,4(1H,3H)-pyrimidinedione
- (1S)-1,4-Anhydro-1-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)-D-ribitol
- m1ψ
Product Documents:
Size | Unit Price | Same Day | 2-3 Business Days |
---|---|---|---|
100MG |
₩421,800
|
13 | 1 |
1G |
₩1,346,800
|
20 | Contact Us |
* Please contact our distributor of SEJIN CI Co., Ltd.
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:
sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
Product Number | M3387 |
Purity / Analysis Method | >99.0%(HPLC) |
Molecular Formula / Molecular Weight | C__1__0H__1__4N__2O__6 = 258.23 |
Physical State (20 deg.C) | Solid |
Storage Temperature | Refrigerated (0-10°C) |
Store Under Inert Gas | Store under inert gas |
Condition to Avoid | Air Sensitive,Heat Sensitive |
Packaging and Container | 100MG-Glass Bottle with Plastic Insert (View image), 1G-Glass Bottle with Plastic Insert (View image) |
CAS RN | 13860-38-3 |
Reaxys Registry Number | 551569 |
MDL Number | MFCD10687017 |
Specifications
Appearance | White to Light yellow powder to crystal |
Purity(HPLC) | min. 99.0 area% |
Purity(qNMR) | min. 98.0 % |
Melting point | 187.0 to 191.0 °C |
Specific rotation | -6.0 to -8.0 deg (C=1, water) |
NMR | confirm to structure |
Properties (reference)
Melting Point | 189 °C |
GHS
Related Laws:
Transport Information:
H.S.code* | 2934.99-000 |
Application
1-Methylpseudouridine (m1Ψ): A Non-Natural Pyrimidine Nucleoside Found in mRNA Vaccines
In recent years, numerous studies have demonstrated the outstanding abilities of mRNA to elicit potent immune, making it a viable new platform for vaccine development1). Additionally there are reports on incorporation of modified nucleobases into mRNA offering advantages for the generation of potent and long-lived antibody responses. In protein biosynthesis, 1-methylpseudouridine (m1Ψ) and pseudouridine (Ψ) [P2939 (synthetic)] [P2396] are read like uridine (U) and enable comparatively high protein yields. Furthermore, m1Ψ enhances immune evasion, protein production, and consequently vaccine efficacy.2-4)
References
- 1) mRNA vaccine for cancer immunotherapy (a review)
- 2) N1-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice
- 3) N1-methyl-pseudouridine in mRNA enhances translation through eIF2α dependent and independent mechanisms by increasing ribosome density
- 4) Modifications in an Emergency: The Role of N1-Methylpseudouridine in COVID-19 Vaccines (a review)
PubMed Literature
Please visit the Pubchem page at this link.
Articles/Brochures
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
Please select Language.
The requested SDS is not available.
Please Contact Us for more information.
Specifications
C of A & Other Certificates
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.
A sample C of A for this product is not available at this time.
Analytical Charts
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
The requested analytical chart is not available. Sorry for the inconvenience.