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CAS RN: 133407-82-6 | Product Number: M3244
MG-132
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Purity: >95.0%(qNMR)
Synonyms:
- Cbz-Leu-Leu-Leu-CHO
- Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal
- Benzyl [(S)-4-Methyl-1-[[(S)-4-methyl-1-[[(S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 10MG |
₩185,000
|
1 | 0 | Contact Us |
* Please contact our distributor of SEJIN CI Co., Ltd.
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:
sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
| Product Number | M3244 |
| Purity / Analysis Method | >95.0%(qNMR) |
| Molecular Formula / Molecular Weight | C__2__6H__4__1N__3O__5 = 475.63 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 133407-82-6 |
| Reaxys Registry Number | 7668447 |
| MDL Number | MFCD00674886 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(qNMR) | min. 95.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 84 °C |
GHS
Related Laws:
| RTECS# | OH2824610 |
Transport Information:
| H.S.code* | 2924.29-000 |
Application
MG-132: A Tripeptide Aldehyde Proteasome Inhibitor
Proteasomes are protein complexes which degrade unneeded or damaged proteins by proteolysis. MG-132 (carbobenzyl-Leu-Leu-Leu-aldehyde) is the first developed tripeptide aldehyde proteasome inhibitor derived from a Chinese medicinal plant. Similarly to bortezomib [B5741], MG-132 inhibits the chymotrypsin-like proteolytic (β5) site of the 26S proteasome. MG-132 enhances cytostatic/cytotoxic effects of chemo- and radiotherapy, and increases apoptosis induced by other agents. (The product is for research purpose only.)
References
- MG132, a proteasome inhibitor, induces apoptosis in tumor cells (a review)
- Functions of the proteasome: from protein degradation and immune surveillance to cancer therapy (a review)
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