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CAS RN: 65277-42-1 | Product Number: K0045
Ketoconazole
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Purity: >98.0%(T)(HPLC)
Synonyms:
- (±)-cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
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|---|---|---|---|---|---|
| 1G |
₩127,700
|
18 | ≥100 | Contact Us | |
| 5G |
₩431,100
|
24 | 7 | Contact Us |
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* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
| Product Number | K0045 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__6H__2__8Cl__2N__4O__4 = 531.43 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 65277-42-1 |
| Reaxys Registry Number | 5488107 |
| PubChem Substance ID | 87560321 |
| Merck Index (14) | 5302 |
| MDL Number | MFCD00058579 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 148.0 to 152.0 °C |
Properties (reference)
| Melting Point | 150 °C |
| Solubility (soluble in) | Methanol |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. H413 : May cause long lasting harmful effects to aquatic life. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | TK7912300 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| H.S.code* | 2934.99-000 |
Application
Studies of Ketoconazole Inhibition of Cytochrome P450
References
- Ketoconazole and sulfaphenazole as the respective selective inhibitors of P4503A and 2C9
- Inhibition of cytochrome P-450 3A (CYP3A) in human intestinal and liver microsomes: comparison of Ki values and impact of CYP3A5 expression
- M. A. Gibbs, K. E. Thummel, D. D. Shen, K. L. Kunze, Drug Metab. Dispos. 1999, 27, 180.
- Cytochrome P450 3A inhibition by ketoconazole affects prasugrel and clopidogrel pharmacokinetics and pharmacodynamics differently
- Sources of variability in ketoconazole inhibition of human cytochrome P450 3A in vitro
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