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CAS RN: 102518-79-6 | Product Number: H1700
(-)-Huperzine A
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Purity: >98.0%(HPLC)
Synonyms:
- (5R,9R,E)-5-Amino-11-ethylidene-7-methyl-5,6,9,10-tetrahydro-5,9-methanocycloocta[b]pyridin-2(1H)-one
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days |
|---|---|---|---|
| 10MG |
₩96,200
|
20 | 27 |
| 100MG |
₩606,800
|
11 | 10 |
* Please contact our distributor of SEJIN CI Co., Ltd.
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:
sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
| Product Number | H1700 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__5H__1__8N__2O = 242.32 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| Packaging and Container | 10MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 102518-79-6 |
| Reaxys Registry Number | 3592896 |
| PubChem Substance ID | 468591999 |
| Merck Index (14) | 4755 |
| MDL Number | MFCD01714949 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 228.0 to 233.0 °C |
| Specific rotation [a]20/D | -144 to -155 deg(C=0.5, MeOH) |
| Water | max. 3.0 % |
Properties (reference)
| Melting Point | 232 °C |
| Specific Rotation | -147° (C=0.5,MeOH) |
| Maximum Absorption Wavelength | 313(EtOH) nm |
GHS
| Pictogram |
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| Signal Word | Danger |
| Hazard Statements | H300 : Fatal if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | PB9185700 |
Transport Information:
| UN Number | UN1544 |
| Class | 6.1 |
| Packing Group | II |
| H.S.code* | 2939.79-000 |
Application
(-)-Huperzine A: A Potent, Highly Specific and Reversible Inhibitor of Acetylcholinesterase
(-)-Huperzine A (HupA), a Lycopodium alkaloid isolated from the Chinese herb Huperzia Serrata, is a potent, highly specific and reversible inhibitor of acetylcholinesterase (AChE). It has been reported that HupA has better penetration through the blood-brain barrier, higher oral bioavailability, and longer duration of AChE inhibitory action, compared with other AChE inhibitors including donepezil [D4099] and rivastigmine [R0093]. Recently, HupA has been used in Alzheimer's disease and other forms of dementia. (The product is for research purpose only.)
References
- The structures of huperzine A and B, two new alkaloids exhibiting marked anticholinesterase activity
- Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A
- The Lycopodium alkaloids (a review)
- Huperzine A from Huperzia serrata: a review of its sources, chemistry, pharmacology and toxicology
- Huperzine A as a neuroprotective and antiepileptic drug: a review of preclinical research
- Liquid chromatographic-tandem mass spectrometric method for the quantitation of huperzine A in dog plasma
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