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CAS RN: 100491-29-0 | Product Number: E1180
Ethyl 7-Chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate
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Purity: >98.0%(HPLC)(N)
Synonyms:
- 7-Chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic Acid Ethyl Ester
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 5G |
₩61,100
|
6 | 1 | It can be shipped in about 2 weeks after ordering | |
| 25G |
₩173,900
|
8 | 19 | It can be shipped in about 2 weeks after ordering |
* Please contact our distributor of SEJIN CI Co., Ltd.
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:
sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
| Product Number | E1180 |
| Purity / Analysis Method | >98.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__1__7H__1__0ClF__3N__2O__3 = 382.72 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 100491-29-0 |
| Reaxys Registry Number | 4766094 |
| PubChem Substance ID | 253661440 |
| MDL Number | MFCD01863285 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 213.0 to 217.0 °C |
Properties (reference)
| Melting Point | 215 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H317 : May cause an allergic skin reaction. H411 : Toxic to aquatic life with long lasting effects. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P273 : Avoid release to the environment. P272 : Contaminated work clothing should not be allowed out of the workplace. P280 : Wear protective gloves. P302 + P352 : IF ON SKIN: Wash with plenty of water. P391 : Collect spillage. P362 + P364 : Take off contaminated clothing and wash it before reuse. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. |
Related Laws:
Transport Information:
| UN Number | UN3077 |
| Class | 9 |
| Packing Group | III |
| H.S.code* | 2933.99-000 |
Application
The Synthesis of Fluoroquinolone Antibiotics
This compound has previously been converted into tosufloxacin [T2506] by reaction with 3-acetamidopyrrolidine [A1108]. To this day, it has been widely used for the synthesis of fluoroquinolone antibiotics such as trovafloxacin.
References
- Synthesis and structure-activity relationships of new arylfluoronaphthyridine antibacterial agents
- Preparation and in vitro and in vivo evaluation of quinolones with selective activity against Gram-positive organisms
- Synthesis of (1α,5α,6α)-6-amino-3-azabicyclo[3.1.0]hexane, a novel achiral diamine
- Diastereoselective syntheses of N-protected derivatives of 1α,5α,6β-6-amino-3-azabicyclo[3.1.0]hexane. A route to trovafloxacin 6β-diastereomer
- Synthesis of trovafloxacin using various (1α,5α,6α)-3-azabicyclo[3.1.0]hexane derivatives
PubMed Literature
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