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CAS RN: 364622-82-2 | Product Number: D5249
Doripenem Monohydrate
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Purity: >98.0%(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days |
|---|---|---|---|
| 50MG |
₩334,900
|
8 | 19 |
| 250MG |
₩1,165,500
|
1 | ≥60 |
* Please contact our distributor of SEJIN CI Co., Ltd.
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:
sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
| Product Number | D5249 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__5H__2__4N__4O__6S__2·H__2O = 438.52 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 250MG-Glass Bottle with Plastic Insert (View image), 50MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 364622-82-2 |
| Related CAS RN | 148016-81-3 |
| Reaxys Registry Number | 15340136 |
| PubChem Substance ID | 354335134 |
| MDL Number | MFCD09749887 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Specific rotation [a]20/D | +32.0 to +37.0 deg(C=1, H2O) |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 12.00 to 13.50 % |
Properties (reference)
| Melting Point | 173 °C(dec.) |
| Specific Rotation | 34° (C=1,H2O) |
GHS
Related Laws:
Transport Information:
| H.S.code* | 2935.90-000 |
Application
Doripenem: A Carbapenem Antibiotic with Broad-Spectrum Activity
Doripenem (S-4661) is a carbapenem antibiotic with broad-spectrum activity against Gram-negative and Gram-positive bacteria, including multidrug-resistant strains and Pseudomonad aeruginosa. Carbapenems, including doripenem, act fungicidally by inhibiting bacterial cell wall biosynthesis by binding to and inactivating penicillin-binding proteins (PBPs) which are essential enzymes for the biosynthesis. In addition, carbapenems are stable to most β-lactamases including AmpC β-lactamases and extended-spectrum β-lactamases. (The product is for research purpose only.)
References
- Doripenem versus Pseudomonas aeruginosa in vitro: Activity against characterized isolates, mutants, and transconjugants and resistance selection potential
- Comparative activity of doripenem and three other carbapenems tested against Gram-negative bacilli with various ＆beta;-lactamase resistance mechanisms
- Doripenem (a review)
- Comparative review of the carbapenems
- Quantification of doripenem in human plasma and peritoneal fluid by high-performance liquid chromatography with ultraviolet detection
- Characterization of the antibiotic doripenem using physicochemical methods - chromatography, spectrophotometry, spectroscopy and thermal analysis
- Stability-indicating RP-HPLC method for analysis of the antibiotic doripenem in pharmaceutical formulation -Comparison to UV spectrophotometry and microbiological assay
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