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CAS RN: 57808-66-9 | Product Number: D4125
Domperidone
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 5-Chloro-1-[1-[3-(2-oxo-1-benzimidazolyl)propyl]-4-piperidyl]benzimidazol-2-one
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 200MG |
₩192,400
|
4 | 0 | It can be shipped in about 2 weeks after ordering | |
| 1G |
₩658,600
|
2 | 6 | It can be shipped in about 2 weeks after ordering |
* Please contact our distributor of SEJIN CI Co., Ltd.
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:
sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
| Product Number | D4125 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__2H__2__4ClN__5O__2 = 425.92 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 200MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 57808-66-9 |
| Reaxys Registry Number | 903774 |
| PubChem Substance ID | 135727073 |
| Merck Index (14) | 3418 |
| MDL Number | MFCD00069256 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
Properties (reference)
| Melting Point | 243 °C(dec.) |
| Solubility in water | Insoluble |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H360 : May damage fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
| RTECS# | DE2275900 |
Transport Information:
| H.S.code* | 2933.99-000 |
Application
Domperidone: A Peripherally Acting Dopamine D2 Receptor Antagonist
Domperidone is a peripherally acting dopamine D2 receptor antagonist with antiemetic properties similar to those of metoclopramide [M2218] . Unlike metoclopramide, however, domperidone does not readily cross the blood-brain barrier. Its antiemetic effect may be due to a combination of gastrokinetic effects and an antagonism of dopamine D2 receptor. Since the 2000s, the US Food and Drug Administration (FDA) have issued a warning about the cardiac safety of domperidone. (The product is for research purpose only.)
References
- Domperidone, a specific in vitro dopamine antagonist, devoid of in vivo central dopaminergic activity
- Domperidone. A review of its pharmacological activity, pharmacokinetics and therapeutic efficacy in the symptomatic treatment of chronic dyspepsia and as an antiemetic (a review)
- Domperidone: a peripherally acting dopamine2-receptor antagonist (a review)
- Cardiac safety concerns for domperidone, an antiemetic and prokinetic, and galactogogue medicine (a review)
- High-performance liquid chromatographic analysis for the determination of domperidone in human plasma
- Simultaneous estimation of paracetamol and domperidone in tablets by reverse phase HPLC method
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