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CAS RN: 71939-50-9 | Product Number: D3793
Dihydroartemisinin
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Purity: >98.0%(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
₩175,800
|
34 | 6 | Contact Us | |
| 5G |
₩506,900
|
≥40 | 27 | Contact Us |
* Please contact our distributor of SEJIN CI Co., Ltd.
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:
sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
| Product Number | D3793 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__5H__2__4O__5 = 284.35 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 71939-50-9 |
| Reaxys Registry Number | 5813803 |
| PubChem Substance ID | 87561556 |
| SDBS (AIST Spectral DB) | 52709 |
| Merck Index (14) | 817 |
| MDL Number | MFCD00274495 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC)(CAD) | min. 98.0 %(Anomeric total) |
Properties (reference)
| Melting Point | 153 °C(dec.) |
GHS
Related Laws:
| RTECS# | KD4165550 |
Transport Information:
| H.S.code* | 2932.99-000 |
Application
Dihydroartemisinin: An Active Metabolite of Antimalaria Artesunate
Dihydroartemisinin is an active metabolite of artesunate [A2191] which is a semi-synthetic derivative of artemisinin [A2118]. Dihydroartemisinin and its analogs have high efficacy against Plasmodium falciparum in the blood stages of the disease. The exact mechanism of action is still not clear, while the endoperoxide (O-O) subunit of the trioxane ring is critical for antimalarial activity. Several lines of evidence indicate that the O-O bond is easily broken by Fe2+, generating a number of reactive radicals oxidatively damage parasite. In clinical, dihydroartemisinin is often used as a combination agent with a partner agent which has a long half-life, such as piperaquine. In addition, after 2000’s, the anti-tumor activities of dihydroartemisinin have been reported. (The product is for research purpose only.)
References
- Review of the clinical pharmacokinetics of artesunate and its active metabolite dihydroartemisinin following intravenous, intramuscular, oral or rectal administration
- Efficacy and safety of dihydroartemisinin-piperaquine
- Dihydroartemisinin is an inhibitor of ovarian cancer cell growth
- Dihydroartemisinin induces apoptosis and sensitizes human ovarian cancer cells to carboplatin therapy
- Dihydroartemisinin inactivates NF-κB and potentiates the anti-tumor effect of gemcitabine on pancreatic cancer both in vitro and in vivo
- Development and validation of a high-performance liquid chromatography-mass spectroscopy assay for determination of artesunate and dihydroartemisinin in human plasma
PubMed Literature
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