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CAS RN: 1163-36-6 | Product Number: C3468
Clemizole Hydrochloride
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Purity: >98.0%(HPLC)
Synonyms:
- 1-(4-Chlorobenzyl)-2-(pyrrolidin-1-ylmethyl)benzimidazole Hydrochloride
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 25MG |
₩267,200
|
8 | 0 | Contact Us | |
| 100MG |
₩805,400
|
4 | 9 | Contact Us |
* Please contact our distributor of SEJIN CI Co., Ltd.
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:
sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
Supplemental Product Information:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| Product Number | C3468 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__9H__2__0ClN__3·HCl = 362.30 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| Packaging and Container | 25MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 1163-36-6 |
| Related CAS RN | 442-52-4 |
| Reaxys Registry Number | 3791565 |
| PubChem Substance ID | 354335133 |
| Merck Index (14) | 2346 |
| MDL Number | MFCD00051435 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 11.00 to 12.00 % |
Properties (reference)
| Melting Point | 241 °C |
| Solubility in water | Soluble |
| Solubility (insoluble in) | Diethyl ether |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | DD6730000 |
Transport Information:
| H.S.code* | 2933.99-000 |
Application
Clemizole Hydrochloride: A Histamine H1 Receptor Antagonist with Anti-Virus and Various Effects
Clemizole hydrochloride is a histamine H1 receptor antagonist1). Recently, it is reported that clemizole inhibits hepatitis C virus (HCV) replication2), and also potently inhibits transient receptor potential channel 5 (TRPC5).3) In addition, clemizole reportedly can be used for the treatment of Dravet syndrome which is often caused by Scn1a mutations, a voltage-gated sodium channel.4) (The product is for research purpose only.)
References
- 1)Comparison of the effects of eleven histamine H1-receptor antagonists on monoamine turnover in the mouse brain
- 2)The hepatitis C virus (HCV) NS4B RNA binding inhibitor clemizole is highly synergistic with HCV protease inhibitors
- 3)Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5
- 4)Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment
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