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CAS RN: 132203-70-4 | Product Number: C2564
Cilnidipine
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Purity: >98.0%(HPLC)
Synonyms:
- 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 2-Methoxyethyl (2E)-3-Phenyl-2-propenyl Ester
- 2-Methoxyethyl (2E)-3-Phenyl-2-propenyl 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
₩136,500
|
9 | 2 | It can be shipped in about 2 weeks after ordering | |
| 5G |
₩436,800
|
4 | 0 | It can be shipped in about 2 weeks after ordering |
* Please contact our distributor of SEJIN CI Co., Ltd.
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:
sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
| Product Number | C2564 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__7H__2__8N__2O__7 = 492.53 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Condition to Avoid | Light Sensitive |
| CAS RN | 132203-70-4 |
| Reaxys Registry Number | 9093961 |
| PubChem Substance ID | 135727151 |
| Merck Index (14) | 2275 |
| MDL Number | MFCD00865853 |
Specifications
| Appearance | Light orange to Yellow to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 5.55 to 5.75 % |
| Melting point | 108.0 to 112.0 °C |
Properties (reference)
| Melting Point | 110 °C |
GHS
Related Laws:
| RTECS# | US7975550 |
Transport Information:
| H.S.code* | 2933.39-000 |
Application
Cilnidipine: A Long-Acting Dual Antagonist of L-Type and N-Type Ca2+ Channels
Cilnidipine (FRC-8653), a dihydropyridine derivative, is a long-acting dual antagonist of L-type Ca2+ channels in vascular smooth muscle and N-type Ca2+ channels in sympathetic nerve terminals that supply blood vessels. Cilnidipine dilates blood vessels by L-type Ca2+ channel antagonism in the vascular smooth muscles, and consequently lower blood pressure. Cilnidipine also inhibits elevation of heart rate and blood pressure under stress by N-type Ca2+ channel antagonism in the sympathetic nerve. (The product is for research purpose only.)
References
- In vitro and ex vivo Ca-antagonistic effect of 2-methoxyethyl (E)-3-phenyl-2-propen-1-yl(±)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl) pyridine-3, 5-dicarboxylate (FRC-8653), a new dihydropyridine derivative
- Dual action of FRC8653, a novel dihydropyridine derivative, on the Ba2+ current recorded from the rabbit basilar artery
- Effect of cilnidipine, a novel dihydropyridine Ca2+-channel antagonist, on N-type Ca2+ channel in rat dorsal root ganglion neurons
- Selectivity of dihydropyridines for cardiac L-type and sympathetic N-type Ca2+ channels
- Cilnidipine: a new generation Ca2+ channel blocker with inhibitory action on sympathetic neurotransmitter release (a review).
- Analytical methodologies for determination of cilnidipine: an overview
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