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CAS RN: 107753-78-6 | Product Number: Z0029
Zafirlukast
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Purity: >98.0%(HPLC)
Synonyms:
- Cyclopentyl N-[3-[[2-Methoxy-4-[[[(2-methylphenyl)sulfonyl]amino]carbonyl]phenyl]methyl]-1-methyl-1H-indol-5-yl]carbamate
- N-[3-[[2-Methoxy-4-[[[(2-methylphenyl)sulfonyl]amino]carbonyl]phenyl]methyl]-1-methyl-1H-indol-5-yl]carbamic Acid Cyclopentyl Ester
- Cyclopentyl [3-[2-Methoxy-4-[(o-tolylsulfonyl)carbamoyl]benzyl]-1-methyl-1H-indol-5-yl]carbamate
- [3-[2-Methoxy-4-[(o-tolylsulfonyl)carbamoyl]benzyl]-1-methyl-1H-indol-5-yl]carbamic Acid Cyclopentyl Ester
Product Documents:
| Size | Unit Price | Saitama (Kawaguchi) | Hyogo (Amagasaki) | Stock in other WH |
Shipping Information
|
|---|---|---|---|---|---|
| 100MG |
¥21,300
|
4 | 1 | It can be shipped in about 2 weeks after ordering |
* Available Stock: Prompt shipment (for products) in Saitama/Hyogo warehouse. Stock In Other WH: Shipment in about 2-3 Business Days from Saitama warehouse. Please contact us
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* The displayed price is the unit price and does not include consumption tax. The unit prices displayed are the latest and are subject to change without notice.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | Z0029 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__3__1H__3__3N__3O__6S = 575.68 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive |
| Packaging and Container | 100MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 107753-78-6 |
| Reaxys Registry Number | 3641829 |
| PubChem Substance ID | 253661584 |
| Merck Index (14) | 10108 |
| MDL Number | MFCD00864775 |
Specifications
| Appearance | White to Gray to Brown powder to crystaline |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 95.0 % |
Properties (reference)
| Solubility in water | Insoluble |
| Solubility (soluble in) | Dimethylformamide |
| Solubility (slightly sol. in) | Acetone |
| Solubility (insoluble in) | Toluene, Methanol |
GHS
Related Laws:
| RTECS# | FB3966200 |
Transport Information:
Application
Zafirlukast: A Competitive and Selective Peptide Leukotriene Receptor Antagonist
Zafirlukast is a competitive and selective peptide leukotriene receptor antagonist. It binds to the CysLT1 receptors competitively with these cysteinyl leukotrienes (LTC4，LTD4 and LTE4). On the other hand, zafirlukast metabolism by cytochrome P450 3A4 (CYP3A4) has been reported.
References
- The preclinical pharmacology of ICI 204219 (a review)
- Characterization of the human cysteinyl leukotriene CysLT1 receptor
- Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor
- Zafirlukast: a review of its pharmacology and therapeutic potential in the management of asthma
- Zafirlukast Metabolism by Cytochrome P450 3A4 Produces an Electrophilic α,β-Unsaturated Iminium Species That Results in the Selective Mechanism-Based Inactivation of the Enzyme
PubMed Literature
Articles/Brochures
TCIMAIL
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Specifications
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