text.skipToContent text.skipToNavigation

Maximum quantity allowed is 999

Please select the quantity

CAS RN: 50679-08-8 | Product Number: T3977

Terfenadine


Purity: >98.0%(HPLC)
Synonyms:
  • α-[4-(1,1-Dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinebutanol
  • 1-[4-(tert-butyl)phenyl]-4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butan-1-ol
Product Documents:
1G
¥13,300
6   It can be shipped from Saitama warehouse on the same day* It can be shipped in about 2 weeks after ordering
5G
¥46,400
7   It can be shipped from Saitama warehouse on the same day* Contact Us
* Available Stock: Prompt shipment (for products) in Saitama/Hyogo warehouse. Stock In Other WH: Shipment in about 2-3 Business Days from Saitama warehouse. Please contact us if you need further information.
* The displayed price is the unit price and does not include consumption tax. The unit prices displayed are the latest and are subject to change without notice.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.

Product Number T3977
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__3__2H__4__1NO__2 = 471.69 
Physical State (20 deg.C) Solid
Storage Temperature Refrigerated (0-10°C)
Store Under Inert Gas Store under inert gas
Condition to Avoid Air Sensitive,Heat Sensitive
Packaging and Container 1G-Glass Bottle with Plastic Insert (View image)
CAS RN 50679-08-8
Reaxys Registry Number 5857899
PubChem Substance ID 468593048
MDL Number

MFCD00079622

Specifications
Appearance White to Light yellow powder to crystal
Purity(HPLC) min. 98.0 area%
Melting point 146.0 to 150.0 °C
NMR confirm to structure
Properties (reference)
Melting Point 148 °C
Maximum Absorption Wavelength 260(EtOH) nm
Solubility in water Insoluble
Degree of solubility in water 0.0963 mg/l   25 °C
Solubility (soluble in) Methanol, Ethanol
GHS
Related Laws:
RTECS# TM4969000
Transport Information:
Application
Terfenadine: A Prodrug of Fexofenadine with Selective H1-Receptor Antagonist Activity

Terfenadine is a prodrug of fexofenadine [F0698] (HCl salt) which is a non-sedative antihistamine with selective H1-receptor antagonist activity. Terfenadine is metabolized by intestinal CYP3A4 to fexofenadine which competitively binds peripheral H1-receptors, thereby stabilizing an inactive conformation of the receptor. Consequently, usual allergic responses as a result of mast-cell degranulation followed by the release of multiple inflammatory mediators, such as interleukins, prostaglandins, and leukotriene precursors, are blocked. In addition, it has been reported that terfenadine may reach excessive blood levels when the metabolism is too slow; and which can cause cardiac arrhythmias (prolongation of QT-interval). (The product is for research purpose only.)

References


Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
Please select Language.

The requested SDS is not available.

Please Contact Us for more information.

Specifications
C of A & Other Certificates
Please enter Lot Number Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.

The product with the lot number searched for has been discontinued and no related documentation is available.

Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.

A sample C of A for this product is not available at this time.

Analytical Charts
Please enter Lot Number Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.

The requested analytical chart is not available. Sorry for the inconvenience.

The product with the lot number searched for has been discontinued and no related documentation is available.

Other Documents

Session Status
Your session will timeout in 10 minutes. You will be redirected to the HOME page after session timeout. Please click the button to continue session from the same page. minute. You will be redirected to the HOME page after session timeout. Please click the button to continue session from the same page.

Your session has timed out. You will be redirected to the HOME page.