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CAS RN: 85416-73-5 | Product Number: R0183

(S)-(+)-Rolipram


Purity: >98.0%(HPLC)
Synonyms:
  • (S)-(+)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one
Product Documents:
10MG
¥13,100
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50MG
¥43,800
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Product Number R0183
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__1__6H__2__1NO__3 = 275.35 
Physical State (20 deg.C) Solid
Storage Temperature Frozen (<0°C)
Condition to Avoid Heat Sensitive
CAS RN 85416-73-5
Reaxys Registry Number 6687797
PubChem Substance ID 354333407
MDL Number

MFCD03093861

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Optical purity(LC) min. 97.0 ee%
Elemental analysis(Nitrogen) 4.50 to 5.50 %
Melting point 132.0 to 136.0 °C
Specific rotation [a]20/D +29.0 to +34.0 deg(C=0.5, MeOH)
NMR confirm to structure
Properties (reference)
Melting Point 134 °C
Specific Rotation 32° (C=0.5,MeOH)
GHS
Related Laws:
Transport Information:
Application
(S)-(+)-Rolipram: The Less Active Enantiomer of Rolipram, PDE4 Inhibitor

(S)-(+)-Rolipram is the less active enantiomer of the PDE4 inhibitor rolipram [R0110]. The active enantiomer (R)-(-)-rolipram [R0182] also available. It has been reported that (S)-(-)-rolipram is approximately 3 times less potent than (R)-(+)-rolipram against PDE4. In 2015, Kobayashi et al. have been reported a new multistep continuous-flow synthesis of (R)- and (S)-rolipram using only columns packed with heterogeneous catalysts. (The product is for research purpose only.)

References


PubMed Literature


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