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CAS RN: 75530-68-6 | Product Number: N0899
Nilvadipine
×
Purity: >95.0%(N)
Deleterious substance
Synonyms:
- 2-Cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 5-Isopropyl 3-Methyl Ester
- 5-Isopropyl 3-Methyl 2-Cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
Product Documents:
| Size | Unit Price | Saitama (Kawaguchi) | Hyogo (Amagasaki) | Stock in other WH |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
¥11,300
|
1 | It can be shipped from Saitama warehouse on the same day* | Contact Us | |
| 5G |
¥37,600
|
5 | 2 | Contact Us |
* Available Stock: Prompt shipment (for products) in Saitama/Hyogo warehouse. Stock In Other WH: Shipment in about 2-3 Business Days from Saitama warehouse. Please contact us
if you need further information.
* The displayed price is the unit price and does not include consumption tax. The unit prices displayed are the latest and are subject to change without notice.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
* The displayed price is the unit price and does not include consumption tax. The unit prices displayed are the latest and are subject to change without notice.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | N0899 |
Purity / Analysis Method 
|
>95.0%(N) |
| Molecular Formula / Molecular Weight | C__1__9H__1__9N__3O__6 = 385.38 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 75530-68-6 |
| Reaxys Registry Number | 3572609 |
| PubChem Substance ID | 135727167 |
| Merck Index (14) | 6545 |
| MDL Number | MFCD00867065 |
Specifications
| Appearance | Light yellow to Amber to Dark green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 95.0 % |
| Melting point | 149.0 to 153.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 151 °C |
| Solubility in water | Insoluble |
| Solubility (soluble in) | Methanol |
| Solubility (slightly sol. in) | Ethanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. |
Related Laws:
| Poisonous or Deleterious | Deleterious substance |
| RTECS# | US7968300 |
Transport Information:
Application
長時間作動型のジヒドロピリジン系L型Ca2+チャンネル受容体アンタゴニスト，ニルバジピン
Nilvadipine is a dihydropyridine-derivative L-type Ca2+ channel receptor antagonist which relaxes arterial smooth muscle with high vascular selectivity and without changing serum calcium concentrations. This leads to prolonged vascular relaxation and lowering of blood pressure. In comparison with nifedipine [N0528], nilvadipine have a longer duration of action and a greater vasodilatory effect. Nilvadipine is mainly metabolized by CYP3A4 in the liver. Nilvadipine is a poorly water soluble agent, and its solid dispersions have been developed to the solubility. (The product is for research purpose only.)
References
- Effects of nilvadipine on the cardiovascular system in experimental animals
- Effects of nilvadipine, a new calcium entry blocker, on systemic blood pressure, cardiac hypertrophy and venous distensibility in spontaneously hypertensive rats
- Nilvadipine: profile of a new calcium antagonist. An overview
- Inhibition of human cytochrome P450 enzymes by 1,4-dihydropyridine calcium antagonists: prediction of in vivo drug-drug interactions
- Dissolution mechanism and rate of solid dispersion particles of nilvadipine with hydroxypropyl methyl cellulose
- Stability study of nilvadipine in bulk drug and pharmaceutical capsules by high performance liquid chromatography
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Specifications
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