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CAS RN: 54-11-5 | Product Number: N0079
Nicotine
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Purity: >95.0%(GC)(T)
Poisonous substance
|Chemical Substance Law (ENCS):
9-990
Synonyms:
- (S)-3-(1-Methyl-2-pyrrolidinyl)pyridine
Product Documents:
| Size | Unit Price | Saitama (Kawaguchi) | Hyogo (Amagasaki) | Stock in other WH |
Shipping Information
|
|---|---|---|---|---|---|
| 25ML |
¥7,700
|
13 | 10 | Contact Us | |
| 100ML |
¥18,700
|
14 | It can be shipped from Saitama warehouse on the same day* | Contact Us | |
| 500ML |
¥63,000
|
It can be shipped in about 2-3 business days after ordering | 8 | Contact Us |
* Available Stock: Prompt shipment (for products) in Saitama/Hyogo warehouse. Stock In Other WH: Shipment in about 2-3 Business Days from Saitama warehouse. Please contact us
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
* The displayed price is the unit price and does not include consumption tax. The unit prices displayed are the latest and are subject to change without notice.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | N0079 |
| Purity / Analysis Method | >95.0%(GC)(T) |
| Molecular Formula / Molecular Weight | C__1__0H__1__4N__2 = 162.24 |
| Physical State (20 deg.C) | Liquid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Hygroscopic |
| CAS RN | 54-11-5 |
| Reaxys Registry Number | 82109 |
| PubChem Substance ID | 87573472 |
| SDBS (AIST Spectral DB) | 6729 |
| Merck Index (14) | 6524 |
| MDL Number | MFCD00006369 |
Specifications
| Appearance | Colorless to Red to Green clear liquid |
| Purity(GC) | min. 95.0 % |
| Purity(Nonaqueous Titration) | min. 95.0 % |
| Specific rotation [a]20/D | -160 to -173 deg(C=10, Acetone) |
Properties (reference)
| Melting Point | -80 °C |
| Boiling Point | 91 °C/3 mmHg |
| Flash point | 95 °C |
| Specific Gravity (20/20) | 1.02 |
| Specific Rotation | -167° (C=10,Acetone) |
| Refractive Index | 1.53 |
| Solubility in water | Completely miscible |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H300 + H310 + H330 : Fatal if swallowed, in contact with skin or if inhaled. H315 : Causes skin irritation. H361 : Suspected of damaging fertility or the unborn child. H370 : Causes damage to organs. H410 : Very toxic to aquatic life with long lasting effects. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P262 : Do not get in eyes, on skin, or on clothing. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P284 : Wear respiratory protection. P391 : Collect spillage. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. P361 + P364 : Take off immediately all contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P302 + P352 + P310 : IF ON SKIN: Wash with plenty of water. Immediately call a POISON CENTER/doctor. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P405 : Store locked up. |
Related Laws:
| Chemical Substance Law (ENCS) |
9-990 |
| Fire Defense Law | Group-4-3-III |
| Poisonous or Deleterious | Poisonous substance |
| RTECS# | QS5250000 |
Transport Information:
| UN Number | UN1654 |
| Class | 6.1 |
| Packing Group | II |
Application
Nicotine: A Nicotinic Acetylcholine Receptors (nAChRs) Agonist
Nicotine (or (-)-(S)-nicotine) is an alkaloid and natural insecticide that acts as an anti-herbivore chemical in tobacco plants. Nicotine acts as a nicotinic acetylcholine receptors (nAChRs) agonist. nAChRs are a family of ligand-gated ion channels. Recent studies have shown that nicotine activates neuronal nAChRs in peripheral and central nervous systems leading to depolarization of cell membranes and elevation of intracellular calcium levels, which are considered to cause stimulation of neurotransmitter release, synaptic transmission, intracellular signal transduction and gene expression.1) Nicotine is also used as a probe agent for phenotyping cytochrome P450 2A6 (CYP2A6) which is involved in the metabolism of nicotine.2) (The product is for research purpose only.)
References
- 1) Mammalian nicotinic acetylcholine receptors: from structure to function (a review)
- 2) Metabolism and disposition kinetics of nicotine (a review)
PubMed Literature
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