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CAS RN: 29216-28-2 | Product Number: M2807
Mequitazine
×
Purity: >98.0%(GC)(T)
Synonyms:
- 10-(Quinuclidin-3-ylmethyl)-10H-phenothiazine
- 10-(1-Azabicyclo[2.2.2]oct-3-ylmethyl)-10H-phenothiazine
Product Documents:
| Size | Unit Price | Saitama (Kawaguchi) | Hyogo (Amagasaki) | Stock in other WH |
Shipping Information
|
|---|---|---|---|---|---|
| 100MG |
¥2,800
|
It can be shipped in about 2-3 business days after ordering | 6 | 24 | |
| 1G |
¥16,300
|
6 | It can be shipped from Saitama warehouse on the same day* | Contact Us |
* Available Stock: Prompt shipment (for products) in Saitama/Hyogo warehouse. Stock In Other WH: Shipment in about 2-3 Business Days from Saitama warehouse. Please contact us
if you need further information.
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* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
* The displayed price is the unit price and does not include consumption tax. The unit prices displayed are the latest and are subject to change without notice.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | M2807 |
Purity / Analysis Method 
|
>98.0%(GC)(T) |
| Molecular Formula / Molecular Weight | C__2__0H__2__2N__2S = 322.47 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Condition to Avoid | Light Sensitive |
| Packaging and Container
|
100MG-Glass Bottle with Plastic Insert (View image), 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 29216-28-2 |
| Reaxys Registry Number | 1150945 |
| PubChem Substance ID | 354333324 |
| Merck Index (14) | 5864 |
| MDL Number | MFCD01706743 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 98.0 % |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 146.0 to 150.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 148 °C |
| Solubility in water | Insoluble |
| Solubility (soluble in) | Ethanol |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | SP5080000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
Application
長時間持続性の選択的ヒスタミンH1-受容体アンタゴニスト，メキタジン
Mequitazine is a long-acting and selective histamine H1-receptor antagonist. Mequitazine also possesses antagonistic activity for leukotrienes (LTs) and platelet activating factor (PAF). In the inhibition process, mequitazine acts to inhibit the Ca2+ release from intracellular calcium store of mast cells. Mequitazine is mainly biotransformed by cytochrome P450 2D6 (CYP2D6) in human liver to yield aromatic hydroxylated and S-oxidized metabolites.
References
- Anti-platelet activating factor, anti-leukotriene D4 and some other antiallergic activities of mequitazine.
- Possible mechanisms of vasoinhibitory effects of mequitazine, an antiallergic agent, on the contractions of isolated rat aorta induced by K+, phenylephrine, 5-hydroxytryptamine, and Ca2+.
- Oxidation of Histamine H1 Antagonist Mequitazine is Catalyzed by Cytochrome P450 2D6 in Human Liver Microsomes
- Pipette tip solid-phase extraction and gas chromatography-mass spectrometry for the determination of mequitazine in human plasma
- Pharmacological study of Mequitazine (LM-209) (II) Anti-allergic action [Article in Japanese]
PubMed Literature
Product Articles
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Specifications
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