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CAS RN: 160970-54-7 | Product Number: I1128
Silodosin
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Purity: >97.0%(GC)(T)
Synonyms:
- (R)-1-(3-Hydroxypropyl)-5-[2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy)ethyl]amino]propyl]indoline-7-carboxamide
Product Documents:
| Size | Unit Price | Saitama (Kawaguchi) | Hyogo (Amagasaki) | Stock in other WH |
Shipping Information
|
|---|---|---|---|---|---|
| 250MG |
¥16,500
|
1 | It can be shipped from Saitama warehouse on the same day* | Contact Us | |
| 1G |
¥41,800
|
It can be shipped in about 2-3 business days after ordering | 8 | Contact Us |
* Available Stock: Prompt shipment (for products) in Saitama/Hyogo warehouse. Stock In Other WH: Shipment in about 2-3 Business Days from Saitama warehouse. Please contact us
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
* The displayed price is the unit price and does not include consumption tax. The unit prices displayed are the latest and are subject to change without notice.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | I1128 |
| Purity / Analysis Method | >97.0%(GC)(T) |
| Molecular Formula / Molecular Weight | C__2__5H__3__2F__3N__3O__4 = 495.54 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image), 250MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 160970-54-7 |
| Reaxys Registry Number | 8175841 |
| PubChem Substance ID | 468592113 |
| MDL Number | MFCD00930170 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(Nonaqueous Titration) | min. 97.0 % |
| Melting point | 105.0 to 109.0 °C |
| Specific rotation | -13.0 to -17.0 deg(C=1, methanol) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 107 °C |
| Solubility in water | Insoluble |
| Solubility (soluble in) | Methanol, Dimethylformamide, Ethanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | NL5994752 |
Transport Information:
Application
Silodosin: A Selective Antagonist of α1A-Adrenoceptor
Silodosin (KMD-3213) is a selective antagonist of α1A-adrenoceptor (AR) subtype. This agent selectively binds to α1A-AR, which are located in the human prostate, bladder base, bladder neck, prostatic capsule, and prostatic urethra. Inhibition of the receptor in these tissues can block the sympathetic nerve transmission and cause smooth muscle to relax, resulting in an improvement in urine flow and a reduction in benign prostatic hypertrophy (BPH) symptoms. For your reference, [T3505] is a synthetic intermediate of silodosin. (The product is for research purpose only.)
References
- KMD-3213, a novel, potent, α1a-adrenoceptor-selective antagonist: characterization using recombinant human α1-adrenoceptors and native tissues
- KMD-3213, a uroselective and long-acting α1a-adrenoceptor antagonist, tested in a novel rat model
- Silodosin, a novel selective α1A -adrenoceptor selective antagonist for the treatment of benign prostatic hyperplasia (a review)
- Determination of silodosin in human plasma by liquid chromatography-tandem mass spectrometry
- シロドシン (KMD-3213) のα1-アドレナリン受容体サブタイプ選択性及び臓器特異性
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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