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CAS RN: 347174-05-4 | Product Number: F1302
Ferrostatin-1
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Purity: >98.0%(HPLC)
Synonyms:
- Ethyl 3-Amino-4-(cyclohexylamino)benzoate
- 3-Amino-4-cyclohexylaminobenzoic Acid Ethyl Ester
Product Documents:
| Size | Unit Price | Saitama (Kawaguchi) | Hyogo (Amagasaki) | Stock in other WH |
Shipping Information
|
|---|---|---|---|---|---|
| 25MG |
¥20,300
|
4 | 17 | ≥40 | |
| 100MG |
¥60,300
|
9 | 1 | Contact Us |
* Available Stock: Prompt shipment (for products) in Saitama/Hyogo warehouse. Stock In Other WH: Shipment in about 2-3 Business Days from Saitama warehouse. Please contact us
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
* The displayed price is the unit price and does not include consumption tax. The unit prices displayed are the latest and are subject to change without notice.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | F1302 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__5H__2__2N__2O__2 = 262.35 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| Packaging and Container | 100MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 347174-05-4 |
| Reaxys Registry Number | 9413226 |
| PubChem Substance ID | 468591907 |
| MDL Number | MFCD08072959 |
Specifications
| Appearance | White to Amber to Dark purple powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 103.0 to 107.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 106 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
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Application
Ferrostatin-1: A Potent and Selective Inhibitor of Ferroptosis
Ferrostatin-1 is a potent and selective inhibitor of ferroptosis which is a form of regulated, oxidative, non-apoptotic cell death. Ferroptosis is characterized by iron-dependent accumulation of reactive oxygen species in lipids and depletion of polyunsaturated fatty acids in cell membranes.1,2) Ferroptosis can be triggered by small molecules or conditions that inhibit glutathione biosynthesis or the glutathione-dependent antioxidant enzyme glutathione peroxidase 4 (GPX4).3,4) (The product is for research purpose only.)
References
- 1) Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models
- 2) Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
- 3) Mechanisms of ferroptosis (a review)
- 4) Lipid peroxidation-dependent cell death regulated by GPx4 and ferroptosis (a review)
Articles/Brochures
TCIMAIL
[Featured Products] Ferroptosis Research Reagents ― for iron-dependent programmed cell death ―Product Documents (Note: Some products will not have analytical charts available.)
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