CAS RN: 571203-78-6 | Product Number: E1524

Erastin

Purity: >98.0%(HPLC)(qNMR)

Synonyms:

2-[1-[4-[2-(4-Chlorophenoxy)acetyl]piperazin-1-yl]ethyl]-3-(2-ethoxyphenyl)quinazolin-4(3H)-one

Product Documents:

Size	Unit Price	Saitama (Kawaguchi)	Hyogo (Amagasaki)	Stock in other WH	Shipping Information
5MG	¥18,000	5	It can be shipped from Saitama warehouse on the same day*	It can be shipped in about 2 weeks after ordering	Shipping Simulation

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General Information plus

Product Number	E1524
Purity / Analysis Method	>98.0%(HPLC)(qNMR)
Molecular Formula / Molecular Weight	C__3__0H__3__1ClN__4O__4 = 547.05
Physical State (20 deg.C)	Solid
Storage Temperature	Frozen (-20°C)
Store Under Inert Gas	Store under inert gas
Condition to Avoid	Air Sensitive,Heat Sensitive
CAS RN	571203-78-6
Reaxys Registry Number	14580272
MDL Number	MFCD09837984

Specifications & Properties plus

Specifications

Appearance	White to Light yellow powder to crystal
Purity(HPLC)	min. 98.0 area%
Purity(qNMR)	min. 98.0 %
NMR	confirm to structure

Properties (reference)

Safety & Regulations plus

GHS

Related Laws:

Transport Information:

Applications plus

Application

Erastin: Inducer of Ferroptosis

References

1) Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
- S. J. Dixon, K. M. Lemberg, M. R. Lamprecht, R. Skouta, E. M. Zaitsev, C. E. Gleason, D. N. Patel, A. J. Bauer, A. M. Cantley, W. S. Yang, B. Morrison III, B. R. Stockwell, Cell 2012, 149, 1060.
2) Ablation of the Ferroptosis Inhibitor Glutathione Peroxidase 4 in Neurons Results in Rapid Motor Neuron Degeneration and Paralysis
- L. Chen, W. S. Hambright, R. Na, Q. Ran, J. Biol. Chem. 2015, 290, 28097.
3) Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
- J. P. F. Angeli, M. Schneider, B. Proneth, Y. Y. Tyurina, V. A. Tyurin, V. J. Hammond, N. Herbach, M. Aichler, A. Walch, E. Eggenhofer, D. Basavarajappa, O. Radmark, S. Kobayashi, T. Seibt, H. Beck, F. Neff, I. Esposito, R. Wank, H. Forster, O. Yefremova, M. Heinrichmeyer, G. W. Bornkamm, E. K. Geissler, S. B. Thomas, B. R. Stockwell, V. B. O’Donnell, V. E. Kagan, J. A. Schick, M. Conrad, Nat. Cell Biol. 2014, 16, 1180.

Application

Erastin: A Ferroptosis Inducer

Erastin is a ferroptosis inducer. Ferroptosis is a type of programmed cell death dependent on iron and characterized by the accumulation of lipid reactive oxygen species. There are reports that erastin inhibits cystine uptake by the cystine/glutamate antiporter (system x_c^-), which helps maintain the redox state. This inhibition creates a void in the cell's antioxidant defenses and ultimately leads to iron-dependent oxidative death (ferroptosis). In addition, activation of ferroptosis results in the non-apoptotic destruction of certain cancer cells. (The product is for research purpose only.)