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CAS RN: 107724-20-9 | Product Number: E0905
Eplerenone
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Purity: >98.0%(HPLC)
Synonyms:
- 9,11α-Epoxy-17-hydroxy-3-oxo-17α-pregn-4-ene-7α,21-dicarboxylic Acid γ-Lactone Methyl Ester
Product Documents:
| Size | Unit Price | Saitama (Kawaguchi) | Hyogo (Amagasaki) | Stock in other WH |
Shipping Information
|
|---|---|---|---|---|---|
| 200MG |
¥20,300
|
34 | It can be shipped from Saitama warehouse on the same day* | Contact Us |
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* The displayed price is the unit price and does not include consumption tax. The unit prices displayed are the latest and are subject to change without notice.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | E0905 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__4H__3__0O__6 = 414.50 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 107724-20-9 |
| Reaxys Registry Number | 7892318 |
| PubChem Substance ID | 160870987 |
| Merck Index (14) | 3625 |
| MDL Number | MFCD07783647 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
Properties (reference)
| Melting Point | 242 °C(dec.) |
| Maximum Absorption Wavelength | 240 nm |
| Solubility (soluble in) | Chloroform, dichloromethane |
| Solubility (slightly sol. in) | Ethanol |
GHS
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Transport Information:
Application
Eplerenone: A Selective Mineralocorticoid Receptor Antagonist
Eplerenone is a mineralocorticoid receptor antagonist. It binds to the receptor and locks the binding of aldosterone, a component of the renin-angiotensin-aldosterone-system (RAAS). Aldosterone binds to mineralocorticoid receptors in tissues, and increases blood pressure through induction of sodium reabsorption and possibly other mechanisms. Eplerenone works by blocking the actions of aldosterone, and resulting in decreasing blood pressure. It is similar to spironolactone [S0260], though it is much more selective for the receptor in comparison. (The product is for research purpose only.)
References
- Three new epoxy-spirolactone derivatives: characterization in vivo and in vitro
- Aldosterone/salt induces renal inflammation and fibrosis in hypertensive rats
- Effects of Long-Term Monotherapy With Eplerenone, a Novel Aldosterone Blocker, on Progression of Left Ventricular Dysfunction and Remodeling in Dogs With Heart Failure
- Cardioprotective mechanisms of eplerenone on cardiac performance and remodeling in failing rat hearts
- Molecular mechanisms of mineralocorticoid receptor antagonism by eplerenone (a review)
- A validated SPE-LC-MS/MS assay for Eplerenone and its hydrolyzed metabolite in human urine
- Stability-indicating RP-HPLC method for analysis of eplerenone in the bulk drug and in a pharmaceutical dosage form
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