Maintenance Notice (12:30 PM - 7:00 PM December 21, 2024): This website is scheduled to be unavailable due to maintenance. We appreciate your patience and understanding.
Published TCIMAIL newest issue No.197 | Notice of Discontinuing the Use of Password-Protected Compressed Files | Product Document Searching Made Easy by 2D Code! | [TCIPracticalExample] Reduction of Amide Group Using...
Maximum quantity allowed is 999
Please select the quantity
CAS RN: 555-30-6 | Product Number: D1817
3-(3,4-Dihydroxyphenyl)-2-methyl-L-alanine Sesquihydrate
×
![]()
×
Purity: >98.0%(T)(HPLC)
Chemical Substance Law (ENCS):
9-636
Synonyms:
- α-Methyl-L-DOPA Sesquihydrate
- Methyldopa Sesquihydrate
Product Documents:
| Size | Unit Price | Saitama (Kawaguchi) | Hyogo (Amagasaki) | Stock in other WH |
Shipping Information
|
|---|---|---|---|---|---|
| 5G |
¥8,000
|
24 | 5 | Contact Us | |
| 25G |
¥23,500
|
20 | It can be shipped from Saitama warehouse on the same day* | Contact Us |
* Available Stock: Prompt shipment (for products) in Saitama/Hyogo warehouse. Stock In Other WH: Shipment in about 2-3 Business Days from Saitama warehouse. Please contact us
if you need further information.
* The displayed price is the unit price and does not include consumption tax. The unit prices displayed are the latest and are subject to change without notice.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
* The displayed price is the unit price and does not include consumption tax. The unit prices displayed are the latest and are subject to change without notice.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | D1817 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__0H__1__3NO__4·1^^1/__2H__2O = 238.24 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Air Sensitive |
| CAS RN | 555-30-6 |
| Related CAS RN | 41372-08-1 |
| Reaxys Registry Number | 2807721 |
| PubChem Substance ID | 87568286 |
| Merck Index (14) | 6055 |
| MDL Number | MFCD00004186 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 %(calcd.on anh.substance) |
| Specific rotation [a]20/D | -12.5 to -14.5 deg(C=1, H2O) |
| Solubility in hot Water | almost transparency |
| Water | 10.0 to 12.0 % |
| NMR | confirm to structure |
Properties (reference)
| Specific Rotation | -14° (C=1,H2O) |
GHS
Related Laws:
| Chemical Substance Law (ENCS) |
9-636 |
| RTECS# | AY5950000 |
Transport Information:
Application
Methyldopa: An Aromatic-Amino Acid Decarboxylase Inhibitor
Methyldopa is an aromatic-amino acid decarboxylase inhibitor. It inhibits the decarboxylation of L-DOPA [D0600], thereby interfering with the formation of dopamine [A0305 (HCl salt)], a precursor of L-norepinephrine [A0906 (bitartrate)]. Methyldopa is an effective anti-hypertensive agent that reduces both supine and standing blood pressure. At first, the anti-hypertensive activity was believed to be related with the inhibition. Nowadays, methyldopa is metabolized to α-methylnorepinephrine and this compound is thought to stimulate central nerve α-adrenergic receptors, producing a decrease in peripheral sympathetic outflow, and resulting in decreasing blood pressure. (The product is for research purpose only.)
References
- Studies on the metabolism and mechanism of action of methyldopa
- α-Sympathetic receptor stimulation in the brain and hypotensive activity of α-methyldopa
- Clinical pharmacokinetics of methyldopa (a review)
- Spectrophotometric determination of methyldopa in pure and pharmaceutical preparations
- Simultaneous determination of serum concentrations of levodopa, dopamine, 3-O-methyldopa and α-methyldopa by HPLC
PubMed Literature
Articles/Brochures
TCIMAIL
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
Please select Language.
The requested SDS is not available.
Please Contact Us for more information.
Specifications
C of A & Other Certificates
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.
A sample C of A for this product is not available at this time.
Analytical Charts
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
The requested analytical chart is not available. Sorry for the inconvenience.