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CAS RN: 145040-37-5 | Product Number: C2635
Candesartan Cilexetil
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Purity: >98.0%(T)(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Saitama (Kawaguchi) | Hyogo (Amagasaki) | Stock in other WH |
Shipping Information
|
|---|---|---|---|---|---|
| 200MG |
¥7,800
|
12 | 1 | 38 | |
| 1G |
¥26,400
|
19 | It can be shipped from Saitama warehouse on the same day* | It can be shipped in about 2 weeks after ordering |
* Available Stock: Prompt shipment (for products) in Saitama/Hyogo warehouse. Stock In Other WH: Shipment in about 2-3 Business Days from Saitama warehouse. Please contact us
if you need further information.
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* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
* The displayed price is the unit price and does not include consumption tax. The unit prices displayed are the latest and are subject to change without notice.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | C2635 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__3__3H__3__4N__6O__6 = 610.67 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image), 200MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 145040-37-5 |
| Reaxys Registry Number | 7328188 |
| PubChem Substance ID | 160871141 |
| Merck Index (14) | 1739 |
| MDL Number | MFCD00871371 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 157.0 to 163.0 °C |
Properties (reference)
| Melting Point | 159 °C |
| Maximum Absorption Wavelength | 304(EtOH) nm |
| Solubility (slightly sol. in) | Methanol |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H360 : May damage fertility or the unborn child. H362 : May cause harm to breast-fed children. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P263 : Avoid contact during pregnancy/ while nursing. P260 : Do not breathe dusts or mists. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
| RTECS# | DD6672500 |
Transport Information:
Application
Candesartan Cilexetili: A Selective AT1 Subtype Angiotensin II Receptor Antagonist
Candesartan cilexetili, a prodrug, is hydrolyzed to candesartan during absorption from the gastrointestinal tract. The active metabolite, candesartan, acts as a selective AT1 subtype angiotensin II receptor antagonist.
Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin-converting enzyme (ACE). Angiotensin II can activate two different receptors, AT1 and AT2, both of which are coupled to G-protein. Angiotensin II is the principal pressor agent of the renin-angiotensin system, and the actions of it are mediate through AT1 receptors. Candesartan has much greater affinity for the AT1 receptor than for the AT2 receptor, and blocks of the AT1 receptor in many tissues by an antagonist suppressed the action of angiotensin II. Candesartan exerts a long-lasting antihypertensive action in spontaneously hypertensive rats. For your reference, [M2797] is a synthetic intermediate of candesartan cilexetili. (The product is for research purpose only.)
Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin-converting enzyme (ACE). Angiotensin II can activate two different receptors, AT1 and AT2, both of which are coupled to G-protein. Angiotensin II is the principal pressor agent of the renin-angiotensin system, and the actions of it are mediate through AT1 receptors. Candesartan has much greater affinity for the AT1 receptor than for the AT2 receptor, and blocks of the AT1 receptor in many tissues by an antagonist suppressed the action of angiotensin II. Candesartan exerts a long-lasting antihypertensive action in spontaneously hypertensive rats. For your reference, [M2797] is a synthetic intermediate of candesartan cilexetili. (The product is for research purpose only.)
References
- Protective effects of candesartan cilexetil (TCV-116) against stroke, kidney dysfunction and cardiac hypertrophy in stroke-prone spontaneously hypertensive rats
- Beneficial effects of candesartan, an angiotensin II type 1 receptor blocker, on beta-cell function and morphology in db/db mice
- The angiotensin II receptor antagonist candesartan cilexetil (TCV-116) ameliorates retinal disorders in rats
PubMed Literature
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