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CAS RN: 151060-21-8 | Product Number: B4354
Balofloxacin Dihydrate
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[3-(methylamino)-1-piperidyl]-4-oxoquinoline-3-carboxylic Acid Dihydrate
Product Documents:
| Size | Unit Price | Saitama (Kawaguchi) | Hyogo (Amagasaki) | Stock in other WH |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
¥7,500
|
3 | It can be shipped from Saitama warehouse on the same day* | Contact Us | |
| 5G |
¥22,800
|
7 | It can be shipped from Saitama warehouse on the same day* | Contact Us |
* Available Stock: Prompt shipment (for products) in Saitama/Hyogo warehouse. Stock In Other WH: Shipment in about 2-3 Business Days from Saitama warehouse. Please contact us
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
* The displayed price is the unit price and does not include consumption tax. The unit prices displayed are the latest and are subject to change without notice.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | B4354 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__0H__2__4FN__3O__4·2H__2O = 425.46 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 151060-21-8 |
| Related CAS RN
|
127294-70-6 |
| Reaxys Registry Number | 8362117 |
| PubChem Substance ID | 253661053 |
| MDL Number | MFCD00864925 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 %(as Dihydrate) |
| Water | 6.5 to 10.5 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 135 °C |
GHS
Related Laws:
| RTECS# | VB1993755 |
Transport Information:
Application
Balofloxacin: An 8-Methoxyfluoroquinolone Antibiotic
Balofloxacin (Q-35) is a fluoroquinolone antibiotic, in which a OMe group is substituted at the 8 position of the quinoline nucleus. In vitro, it has a broad spectrum of activity against Gram-positive bacteria (eg. Mycoplasma pneumoniae and Staphylococcus aureus including MRSA) which is almost equal to that of sparfloxacin [S0896] or tosufloxacin [T2506]. In contrast, its activity against Gram-negative bacteria is lower. In animal studies, balofloxacin do not exhibit any phototoxicity which is a toxicity of fluoroquinolone antibiotic, in general.
References
- In vitro and in vivo activities of Q-35, a new fluoroquinolone, against Mycoplasma pneumoniae
- Improved bactericidal activity of Q-35 against quinolone-resistant staphylococci
- Photostability and biological activity of fluoroquinolones substituted at the 8 position after UV irradiation
- Reduced phototoxicity of a fluoroquinolone antibacterial agent with a methoxy group at the 8 position in mice irradiated with long-wavelength UV light
- Laboratory and clinical study of balofloxacin (Q-35), a new fluoroquinolone, in urinary tract infection
- Development and validation of analytical method for estimation of Balofloxacin in bulk and pharmaceutical dosage form
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