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CAS RN: 117772-70-0 | Product Number: A2076
Azithromycin Dihydrate
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Purity: >98.0%(N)
Synonyms:
Product Documents:
| Size | Unit Price | Saitama (Kawaguchi) | Hyogo (Amagasaki) | Stock in other WH |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
¥7,700
|
5 | 5 | ≥100 | |
| 5G |
¥24,400
|
≥40 | 7 | ≥100 |
* Available Stock: Prompt shipment (for products) in Saitama/Hyogo warehouse. Stock In Other WH: Shipment in about 2-3 Business Days from Saitama warehouse. Please contact us
if you need further information.
* The displayed price is the unit price and does not include consumption tax. The unit prices displayed are the latest and are subject to change without notice.
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
* The displayed price is the unit price and does not include consumption tax. The unit prices displayed are the latest and are subject to change without notice.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
Supplemental Product Information:
This product has not been tested for potency and is guaranteed for chemical purity.
| Product Number | A2076 |
Purity / Analysis Method 
|
>98.0%(N) |
| Molecular Formula / Molecular Weight | C__3__8H__7__2N__2O__1__2·2H__2O = 785.03 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 117772-70-0 |
| Related CAS RN
|
83905-01-5 |
| Reaxys Registry Number | 4776338 |
| PubChem Substance ID | 87560212 |
| SDBS (AIST Spectral DB) | 52117 |
| Merck Index (14) | 915 |
| MDL Number | MFCD01862248 |
Specifications
| Appearance | White powder to crystal |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Specific rotation [a]20/D | -45.0 to -49.0 deg(C=2, EtOH)(calcd.on anh.substance) |
| Water | 4.0 to 5.0 % |
Properties (reference)
| Specific Rotation | -47° (C=2,EtOH) |
| Solubility (soluble in) | Methanol |
GHS
Related Laws:
Transport Information:
Application
Biofilm research
By comparing the results by different biofilm quantitation techniques, effect of azithromycin on biofilm formation in Staphylococcus aureus has been reported.1) According to the report, although the significance rate was low, exposure to sub-minimum inhibitory concentration (sub-MIC) doses of azithromycin showed to induce the biofilm-forming capacity of S. aureus via increasing the total biomass without affecting the bacterial growth of viable count.
(The product is for research purpose only.)
(The product is for research purpose only.)
Reference
- 1) Antimicrobial Sub-MIC induces Staphylococcus aureus biofilm formation without affecting the bacterial count
- Azithromycin: a review of its antimicrobial activity, pharmacokinetic properties and clinical efficacy
- The macrolides: erythromycin, clarithromycin, and azithromycin (a review)
- Macrolide-induced clinically relevant drug interactions with cytochrome P-450A (CYP) 3A4: an update focused on clarithromycin, azithromycin and dirithromycin (a review)
- Analysis of macrolide antibiotics (a review)
- Development, characterization and solubility study of solid dispersions of azithromycin dihydrate by solvent evaporation method
Application
Azithromycin: A More Acid-Stable Semi-Synthetic Macrolide Antibiotic
Macrolide antibiotics are classified by the size of the macrocyclic lactone ring of aglycone as 14-, 15- or 16-membered ring macrolides. Macrolides are characterized by similar chemical structures, mechanisms of action and resistance, but vary in the different pharmacokinetic parameters, and spectrum of activity. Azithromycin (abbrev: AZM), the first azalide macrolide, is chemically synthesized from erythromycin [E0751], with a methyl-substituted nitrogen atom incorporated into the acid-stable lactone ring, thus making the 15-membered lactone ring. AZM is marginally less active than erythromycin in vitro against Gram-positive organisms, but is more active than erythromycin and clarithromycin [C2220] against many Gram-negative pathogens including Haemophilus influenzae and Neisseria gonorrhoeae, and Mycoplasma pneumoniae. However, erythromycin-resistant organisms are also resistant to AZM. AZM is subsequently slowly released, reflecting its long terminal phase elimination half-life relative to that of erythromycin. AZM inhibits protein synthesis in susceptible organisms by binding to specific nucleotides in 23S rRNA within the 50S subunit of the bacterial ribosome.
References
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