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Published TCIMAIL newest issue No.197
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Ferroptosis Research Reagents ― for iron-dependent programmed cell death ―
(Modified from Reference 1)
Ferroptosis is a recently recognized form of regulated cell death characterized by the accumulation of lipid peroxidation products and lethal reactive oxygen species (ROS) derived from iron metabolism. Activation of mitochondrial voltage-dependent anion channels and mitogen-activated protein kinases, upregulation of endoplasmic reticulum stress, and inhibition of cystine/glutamate antiporter is involved in the induction of ferroptosis.
Morphologically, it is characterized by the presence of smaller than normal mitochondria with condensed mitochondrial membrane densities, reduction or vanishing of mitochondria crista, and outer mitochondrial membrane rupture.
Ferroptosis Inhibitors
- H0726
- Trolox
Inhibitor of ferroptosis; antioxidant - T2721
- Baicalein
Inhibitor of ferroptosis; 5- and 1-lipoxygenase inhibitor - C1971
- Coenzyme Q10 (= CoQ10)
Inhibitor of ferroptosis; antioxidant - E0946
- Ebselen
Inhibitor of ferroptosis; Inhibits lipoxygenase, cyclooxygenase nitric oxide synthase, protein kinase C and H+/K+-ATPase activity. Inhibits the hepatic carcinogenic effects of aflatoxin B1. - I0848
- Idebenone
Inhibitor of ferroptosis; blocks glutamate neurotoxicity in vitro and in vivo - F1302
- Ferrostatin-1
Inhibitor of ferroptosis
Ferroptosis Activators
- G0059
- L-Glutamic Acid
Induces ferroptosis; endogenous, non-selective agonist - S0509
- Simvasatin
Induces ferroptosis; HMG-CoA reductase inhibitor - S0580
- Sulfasalazine
Induces ferroptosis; cystine-glutamate antiporter inhibitor and inhibitor of NF-κB activation
Reference
- 1) Ferroptosis: Death by Lipid Peroxidation
