Maintenance Notice (4:30 AM - 11:00 AM December 21, 2024): This website is scheduled to be unavailable due to maintenance. We appreciate your patience and understanding.
Published TCIMAIL newest issue No.197
Maximum quantity allowed is 999
Please select the quantity
CAS RN: 878376-35-3 | Product Number: P2398
Pyridine-2-sulfonyl Fluoride
×
![]()
×
Purity: >98.0%(GC)(T)
Synonyms:
- PyFluor
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
€188.00
|
1 | ≥40 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | P2398 |
| Purity / Analysis Method | >98.0%(GC)(T) |
| Molecular Formula / Molecular Weight | C__5H__4FNO__2S = 161.15 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Moisture Sensitive,Heat Sensitive |
| CAS RN | 878376-35-3 |
| Reaxys Registry Number | 10151877 |
| PubChem Substance ID | 354333991 |
| MDL Number | MFCD09265513 |
Specifications
| Appearance | White to Almost white powder to lump |
| Purity(GC) | min. 98.0 % |
| Purity(Neutralization titration) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 26 °C |
| Flash point | 96 °C |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H314 : Causes severe skin burns and eye damage. H290 : May be corrosive to metals. |
| Precautionary Statements | P260 : Do not breathe dust. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water. P301 + P330 + P331 : IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor. |
Related Laws:
Transport Information:
| UN Number | UN3261 |
| Class | 8 |
| Packing Group | II |
| HS Number | 2933399990 |
Application
TCI Practical Example: Fluorination of an Alcohol Using PyFluor
-
Used Chemicals
-
Procedure
-
A solution of PyFluor (513 mg, 3.19 mmol) in dry toluene (3.6 mL) was added to a solution of 2,3-O-isopropylidene-D-ribonic γ-lactone (500 mg, 2.66 mmol) and DBU (0.79 mL, 5.31 mmol) in toluene (3.0 mL) at 0 °C, and the solution was stirred at room temperature for one day. The reaction mixture was quenched with water (10 mL) and the aqueous layer was extracted with ethyl acetate (3 x 5 mL). The combined organic layer was washed with sat. NH4Cl aq. and brine, dried over anhydrous sodium sulfate and filtered. The solvent was removed under reduced pressure and the residue was purified by column chromatography (ethyl acetate:hexane = 0:100 - 15:85 on silica gel) to give the fluorinated compound 1 as a white solid (309 mg, 61% yield.).
-
Experimenter’s Comments
-
The reaction mixture was monitored by TLC (ethyl acetate:hexane = 1:2, Rf = 0.33).
It was easy to weigh PyFluor after melting PyFluor by heating with hot water bath because the melting point is 26 °C.
-
Analytical Data
-
Fluorinated Compound 1
1H NMR (270 MHz, DMSO-d6); δ 4.94-4.74 (m, 4H), 4.64 (ddd, J = 3.0, 10.8, 27.8 Hz, 1H), 1.37 (s, 3H), 1.33 (s, 3H).
-
Lead Reference
-
- PyFluor: A Low-Cost, Stable, and Selective Deoxyfluorination Reagent
Application
PyFluor: A Stable Deoxyfluorinating Agent
Experimental procedure: A vial is charged sequentially with substrate (1.0 mmol), toluene (1 mL, 1.0 mol/L), PyFluor (177 mg, 1.1 eq.), and DBU (300 µL, 2 eq.). PyFluor is dispensed as a liquid (m.p. 23 – 26 °C). The mixture is stirred at room temperature for 48 hours under ambient atmosphere. Occasionally, an exotherm is observed following addition of base, corresponding to sulfonate ester formation. Reaction progress is accompanied by formation of pale yellow to dark orange precipitates. Products are isolated by column chromatography.
References
- PyFluor: A Low-Cost, Stable, and Selective Deoxyfluorination Reagent
PubMed Literature
Articles/Brochures
TCIMAIL
[TCI Practical Example] Deoxygenative Fluorination of an Alcohol Using PyFluor[Product Highlights] PyFluor: A Stable Deoxyfluorinating Agent
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
Please select Language.
The requested SDS is not available.
Please Contact Us for more information.
Specifications
C of A & Other Certificates
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.
A sample C of A for this product is not available at this time.
Analytical Charts
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
The requested analytical chart is not available. Sorry for the inconvenience.