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Published TCIMAIL newest issue No.198
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CAS RN: 55268-74-1 | Product Number: P2125
Praziquantel
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Purity: >98.0%(HPLC)(N)
Synonyms:
- 2-(Cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
€32.00
|
Contact Us | ≥100 |
|
| 25G |
€104.00
|
3 | 24 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | P2125 |
Purity / Analysis Method 
|
>98.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__1__9H__2__4N__2O__2 = 312.41 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 55268-74-1 |
| Reaxys Registry Number | 761557 |
| PubChem Substance ID | 253659951 |
| Merck Index (14) | 7716 |
| MDL Number | MFCD00058531 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 137.0 to 141.0 °C |
Properties (reference)
| Melting Point | 140 °C |
| Maximum Absorption Wavelength | 271 nm |
| Solubility in water | Insoluble |
| Degree of solubility in water | 0.4 g/l |
| Solubility (soluble in) | Methanol, Ethanol |
GHS
Related Laws:
| EC Number | 259-559-6 |
| RTECS# | UQ4150000 |
Transport Information:
| HS Number | 2933599590 |
Application
Praziquantel: An Anthelmintic Agent for Schistosoma and Liver Fluke
Praziquantel (abbr.: PZQ), an anthelmintic agent, is used to treat schistosoma and liver fluke from 1980s. Although its mechanism of action remains unknown exactly, there are some reports that PZQ increases the permeability of the membranes of schistosoma cells towards calcium ions. PZQ thereby induces contraction of the schistosoma, resulting in paralysis in the contracted state.
References
- Praziquantel (a review)
- Resistance to praziquantel: direct evidence from Schistosoma mansoni isolated from Egyptian villagers
- PLGA nanoparticles containing praziquantel: effect of formulation variables on size distribution
- Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis
PubMed Literature
Product Documents (Note: Some products will not have analytical charts available.)
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