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Published TCIMAIL newest issue No.197
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CAS RN: 920-66-1 | Product Number: H0424
1,1,1,3,3,3-Hexafluoropropan-2-ol
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Purity: >99.0%(GC)
Synonyms:
- 1,1,1,3,3,3-Hexafluoro-2-propanol
- 1,1,1,3,3,3-Hexafluoroisopropyl Alcohol
- HFP
- HFIP
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25G |
€46.00
|
30 | ≥100 |
|
| 100G |
€123.00
|
≥100 | ≥100 |
|
| 500G |
€395.00
|
≥60 | ≥100 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | H0424 |
| Purity / Analysis Method | >99.0%(GC) |
| Molecular Formula / Molecular Weight | C__3H__2F__6O = 168.04 |
| Physical State (20 deg.C) | Liquid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 920-66-1 |
| Reaxys Registry Number | 1841007 |
| PubChem Substance ID | 87570824 |
| SDBS (AIST Spectral DB) | 5259 |
| MDL Number | MFCD00011651 |
Specifications
| Appearance | Colorless to Almost colorless clear liquid |
| Purity(GC) | min. 99.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | -4 °C |
| Boiling Point | 58 °C |
| Specific Gravity (20/20) | 1.62 |
| Refractive Index | 1.28 |
| Maximum Absorption Wavelength | 229 nm |
| Solubility in water | Soluble |
| Solubility (soluble in) | Ether, Acetone |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H302 + H332 : Harmful if swallowed or if inhaled. H314 : Causes severe skin burns and eye damage. |
| Precautionary Statements | P261 : Avoid breathing mist or vapours. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water. P301 + P330 + P331 : IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor. |
Related Laws:
| EC Number | 213-059-4 |
| RTECS# | UB6450000 |
Transport Information:
| UN Number | UN1760 |
| Class | 8 |
| Packing Group | III |
| HS Number | 2905599890 |
Application
1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP or HFP): A Solvent with Specific Properties
1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP or HFP) is used as a solvent with specific properties. Its combination of high H bonding donor ability, low nucleophilicity, and high ionizing power allows reactions to proceed under mild conditions, which usually require the use of added reagents or metal catalysts to be carried out. In addition, HFIP is used as acid in volatile buffers for ion pair HPLC.
References
- Fluorinated alcohols: A new medium for selective and clean reaction (a review)
- 1,1,1,3,3,3-Hexafluoro-2-propanol (a review of the properties, handling and applications)
- 1,1,1,3,3,3-Hexafluoro-2-propanol for the removal of the 4,4'-dimethoxytrityl protecting group from the 5'-hydroxyl of acid-sensitive nucleosides and nucleotides
- New TFA-Free Cleavage and Final Deprotection in Fmoc Solid-Phase Peptide Synthesis: Dilute HCl in Fluoro Alcohol
- Making radical cations live longer
- Analysis of Oligonucleotides by HPLC-Electrospray Ionization Mass Spectrometry
PubMed Literature
Articles/Brochures
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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Other Documents
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1,1,1,3,3,3-Hexafluoropropan-2-ol [for HPLC]
| Product # | H1793 |
| CAS RN | 920-66-1 |
| Purity / Analysis Method: | >99.5%(GC) |