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Published TCIMAIL newest issue No.197
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CAS RN: 22457-89-2 | Product Number: B4711
Benfotiamine
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Purity: >98.0%(T)(HPLC)
Synonyms:
- S-Benzoylthiamine O-Monophosphate
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
€47.00
|
1 | ≥80 |
|
| 25G |
€149.00
|
2 | 22 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | B4711 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__9H__2__3N__4O__6PS = 466.45 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 22457-89-2 |
| Reaxys Registry Number | 771326 |
| PubChem Substance ID | 253662524 |
| Merck Index (14) | 1041 |
| MDL Number | MFCD00057343 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
Properties (reference)
| Melting Point | 192 °C(dec.) |
GHS
Related Laws:
| EC Number | 245-013-4 |
| RTECS# | DH6910000 |
Transport Information:
| HS Number | 2933599590 |
Application
Paraptosis research
Reference
- Paraptosis Cell Death Induction by the Thiamine Analog Benfotiamine in Leukemia Cells
- Pharmacokinetics of thiamine derivatives, especially of benfotiamine (a review)
- D. Loew, Int. J. Clin. Pharmacol. Ther. 1996, 34, 47.
- Efficacy of benfotiamine versus thiamine on function and glycation products of peripheral nerves in diabetic rats
- Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy
- Benfotiamine prevents macro- and microvascular endothelial dysfunction and oxidative stress following a meal rich in advanced glycation end products in individuals with type 2 diabetes
- The multifaceted therapeutic potential of benfotiamine (a review)
Application
Benfotiamine: S-Acyl Derivative of Thiamine with High Bioavailability
S-benzoylthiamine O-monophoshate (benfotiamine) is a synthetic S-acyl derivative of thiamine (vitamin B1). Benfotiamine is absorbed in vivo much more than water soluble thiamine hydrochloride [T0181]. Benfotiamine increases the levels of intracellular thiamine diphosphate, a cofactor necessary for the activation transketolase, resulting in the reduction of tissue level of advanced glycation end products (AGEs) which can be a factor in the development or worsening of many degenerative diseases, such as diabetes, atherosclerosis, chronic renal failure and Alzheimer's disease.
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